Mixed-ligand complex [Cu4(bpy)4(PO4)2(CO3)(H2O)2]: synthesis, crystal structure and biological properties

K. A. Koshenskova; Кошенскова К. А.; N. V. Makarenko; Макаренко Н. В.; D. E. Baravikov; Баравиков Д. Е.; F. M. Dolgushin; Долгушин Ф. М.; O. B. Bekker; Беккер О. Б.; I. L. Eremenko; Еременко И. Л.; I. A. Lutsenko; Луценко И. А.

doi:10.31857/S0132344X23600455

Mixed-ligand complex [Cu4(bpy)4(PO4)2(CO3)(H2O)2]: synthesis, crystal structure and biological properties

Authors: Koshenskova K.A.¹, Makarenko N.V.², Baravikov D.E.¹^,3, Dolgushin F.M.¹, Bekker O.B.⁴, Eremenko I.L.¹^,5, Lutsenko I.A.¹
Affiliations:
1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
2. Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia
3. Mendeleev University of Chemical Technology of Russia, Moscow, Russia
4. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
5. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
Issue: Vol 49, No 12 (2023)
Pages: 752-759
Section: Articles
URL: https://bakhtiniada.ru/0132-344X/article/view/162367
DOI: https://doi.org/10.31857/S0132344X23600455
EDN: https://elibrary.ru/LQRIPR
ID: 162367

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Abstract
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Abstract

The interaction in the system {Сu(OAc)2·H2O–phytic acid–2,2`-bipyridine (bpy)} in an aqueous-methanol solution led to the formation of a molecular mixed-ligand tetranuclear complex [(Cu4(bpy)4(PO4)2(CO3 )(H2O)2]13H2O (I), the structure of which was established based on the results of an X-ray diffraction experiment (CCDC 2262998). According to X-ray diffraction data, the molecule contains four nonequivalent Cu2+ cations, which coordinate two phosphate anions (PO43-, remaining as a result transformation of the phytate cycle), four neutral bpy, two water molecules and one carbonate anion fragment (CO32-). The presence of a large number of solvate water molecules in the outer coordination sphere created a hydrogen-bonded framework involved in the stabilization of the crystal packing. Study of antimycobacterial activity of I in against the non-pathogenic strain Mycolicibacterium smegmatis showed its high bioeffectiveness.

Keywords

copper(II), coordination compound, synthesis, crystal structure, biological activity, Mycolicibacterium smegmatis

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