电邮这篇文章 Development of a Dosage Form of the New Antitumor Antibiotic Olivamide
- 作者: Tevyashova A.N.1,2, Bychkova E.N.1, Dezhenkova L.G.1, Shchekotikhin A.E.1,2
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隶属关系:
- G. F. Gause Institute of New Antibiotics (GINA)
- D. Mendeleev University of Chemical Technology of Russia
- 期: 卷 52, 编号 11 (2019)
- 页面: 930-935
- 栏目: Drug Synthesis Methods and Manufacturing Technology
- URL: https://bakhtiniada.ru/0091-150X/article/view/245540
- DOI: https://doi.org/10.1007/s11094-019-01928-x
- ID: 245540
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详细
Methods for selective chemical modification of the antitumor antibiotic olivomycin A(OA) were developed at GINA. The compound olivamide with advantages over starting OA was selected from series of OA analogs. The goal of the present work was to develop a dosage form of the antitumor semi-synthetic antibiotic olivamide that guaranteed the stability and high specific activity of olivamide drug substance and was designed for further comprehensive preclinical studies.
作者简介
A. Tevyashova
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
编辑信件的主要联系方式.
Email: chulis@mail.ru
俄罗斯联邦, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
E. Bychkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
俄罗斯联邦, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
L. Dezhenkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
俄罗斯联邦, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
A. Shchekotikhin
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Email: chulis@mail.ru
俄罗斯联邦, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
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