Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]Dodec-11-EN-4-YL)Ureas

B. A. Selivanov; A. Y. Tikhonov; E. F. Belanov; N. I. Bormotov; A. S. Kabanov; O. Yu. Mazurkov; O. A. Serova; L. N. Shishkina; A. P. Agafonov; A. N. Sergeev

doi:10.1007/s11094-017-1629-9

Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0^2,6.0^8,10]Dodec-11-EN-4-YL)Ureas

作者: Selivanov B.A.¹, Tikhonov A.Y.¹, Belanov E.F.², Bormotov N.I.², Kabanov A.S.², Mazurkov O.Y.², Serova O.A.², Shishkina L.N.², Agafonov A.P.², Sergeev A.N.²
隶属关系:
1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)
2. VECTOR State Research Center of Virology and Biotechnology
期: 卷 51, 编号 6 (2017)
页面: 439-443
栏目: Article
URL: https://bakhtiniada.ru/0091-150X/article/view/244643
DOI: https://doi.org/10.1007/s11094-017-1629-9
ID: 244643

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详细

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.

关键词

arylisocyanates, arylisothiocyanates, 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)ureas, smallpox vaccines, antiviral activity, pharmacological activity

作者简介

B. Selivanov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

编辑信件的主要联系方式.
Email: seliboba@nioch.nsc.ru
俄罗斯联邦, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090

A. Tikhonov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Email: seliboba@nioch.nsc.ru
俄罗斯联邦, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090