Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by  1 H NMR Spectroscopy

N. E. Kuz’mina; S. V. Moiseev; V. I. Krylov; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1435-9

Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by ¹H NMR Spectroscopy

作者: Kuz’mina N.E.¹, Moiseev S.V.¹, Krylov V.I.¹, Yashkir V.A.¹, Merkulov V.A.¹
隶属关系:
1. Scientific Center for Expert Evaluation of Medical Products, Russian Ministry of Health
期: 卷 50, 编号 4 (2016)
页面: 265-269
栏目: Article
URL: https://bakhtiniada.ru/0091-150X/article/view/244358
DOI: https://doi.org/10.1007/s11094-016-1435-9
ID: 244358

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Amethod for determining molar substitution of hydroxyethylstarches by ¹H NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used to evaluate the parameter “molar substitution” in the framework of pharmacological expert assessment of hydroxyethylstarches as components of medicines.