Мақаланы E-mail арқылы жіберу Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma
- Авторлар: Sokolova A.S.1,2, Yarovaya O.I.1,2, Nefedov A.A.1,2, Salakhutdinov N.F.1,2
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Мекемелер:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State University
- Шығарылым: Том 51, № 12 (2018)
- Беттер: 1102-1105
- Бөлім: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://bakhtiniada.ru/0091-150X/article/view/244929
- DOI: https://doi.org/10.1007/s11094-018-1748-y
- ID: 244929
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Аннотация
A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.
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Авторлар туралы
A. Sokolova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Хат алмасуға жауапты Автор.
Email: a.s.sokolova@mail.ru
Ресей, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
O. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Ресей, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
A. Nefedov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Ресей, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Ресей, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
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