Influence of N,N′-Substituted Piperazines on Cytolysis


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Аннотация

The hemolytic activity of N,N′-substituted piperazines and their influence on the hemolytic process initiated by radiation (red LED, 653 nm) in the presence of radachlorin (RADA-FARMA, Russia) photosensitizer and on complement-dependent hemolysis were studied. All compounds did not cause human RBC lysis in the studied concentration range (0.15 – 3.0 mM) although dose-dependent inhibition of photo-induced hemolysis that manifested as an increase of the 50% lysis time was observed. The piperazine derivatives did not substantially influence RBC lysis by the activated complement. Therefore, the antihemolytic effect of the N,N’-substituted piperazines was due to their antioxidant activity.

Авторлар туралы

O. Veselkina

Vertex Co.

Email: chem@folium.ru
Ресей, 27A 24-th Liniya, St. Petersburg, 199106

I. Solovtsova

Pavlov First St. Petersburg State Medical University, MH RF; Peter the Great St. Petersburg Polytechnic University

Email: chem@folium.ru
Ресей, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022; 5 Khlopina St., St. Petersburg, 195251

N. Petrishchev

Pavlov First St. Petersburg State Medical University, MH RF

Email: chem@folium.ru
Ресей, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022

L. Galebskaya

Pavlov First St. Petersburg State Medical University, MH RF

Email: chem@folium.ru
Ресей, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022

M. Borovitov

Vertex Co.

Email: chem@folium.ru
Ресей, 27A 24-th Liniya, St. Petersburg, 199106

D. Nilov

Vertex Co.

Email: chem@folium.ru
Ресей, 27A 24-th Liniya, St. Petersburg, 199106

M. Solov’eva

Pavlov First St. Petersburg State Medical University, MH RF

Email: chem@folium.ru
Ресей, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022

E. Vorob’ev

Pavlov First St. Petersburg State Medical University, MH RF

Email: chem@folium.ru
Ресей, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022

K. Len’shina

Pavlov First St. Petersburg State Medical University, MH RF

Email: chem@folium.ru
Ресей, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022

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