EFFECT OF GLYCOLYSIS SUPRESSION ON ULTRASTRUCTURE OF THE HIPPOCAMPAL GIANT SYNAPSES

Z. N. Zhuravleva; Журавлева З. Н.; A. E. Malkov; Мальков А. Е.; I. Yu. Popova; Попова И. Ю.

doi:10.31857/S0044467723010124

EFFECT OF GLYCOLYSIS SUPRESSION ON ULTRASTRUCTURE OF THE HIPPOCAMPAL GIANT SYNAPSES

Авторлар: Zhuravleva Z.N.¹, Malkov A.E.¹, Popova I.Y.¹
Мекемелер:
1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Шығарылым: Том 73, № 1 (2023)
Беттер: 94-101
Бөлім: КЛЕТОЧНАЯ НЕЙРОФИЗИОЛОГИЯ
URL: https://bakhtiniada.ru/0044-4677/article/view/136083
DOI: https://doi.org/10.31857/S0044467723010124
EDN: https://elibrary.ru/GJVGFJ
ID: 136083

Дәйексөз келтіру

Толық мәтін

Аннотация
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

Suppression of glycolysis in the rat hippocampal formations was induced by daily intracerebroventricular injection of 2-deoxy-D-glucose for 10 days. Using electron microscopy, a disturbance of morphological interactions of axonal terminals of granular neurons with perisynaptic astrocytic processes was found. At the same time, both the determinant ultrastructural characteristics of giant synapses and two types of functional contacts (asymmetric chemical active zones with dendritic spines and symmetric adhesive junctions with dendrites) were retained. However, they showed morphological signs of a weakening of synaptic processes, which were expressed in a decrease in the number of intraterminal active zones, clustering of synaptic vesicles, and their removal from neurotransmitter release sites. Compared to the norm, an increase in the number of small mitochondria with an electron-dense matrix and the evidence of initiation of glycogen synthesis in the form of glycosomes were found in the giant terminals. The data obtained indicate that the giant synapses of the hippocampal mossy fibers are a plastic, self-correcting system that is able to function by adapting its own bioenergetic metabolism, when brain glycolysis is suppressed.

Негізгі сөздер

hippocampal formation, ultrastructure, giant synaptic endings, glycolysis, 2-deoxy-D-glucose, synaptic vesicles, presynaptic mitochondria, glycosomes

Әдебиет тізімі

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