Современный консенсус относительно диагностики и лечения экстрамаммарного рака Педжета
- Авторы: Емельянова О.О.1, Зикиряходжаев А.Д.1,2,3, Сарибекян Э.К.1, Филоненко Е.В.1,2
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Учреждения:
- Московский нaучнo-иccлeдoвaтeльcкий oнкoлoгичecкий инcтитут имeни П. A. Гepцeнa — филиaл Нaциoнaльного медицинского иccлeдoвaтeльcкого цeнтpа paдиoлoгии
- Poccийcкий унивepcитeт дpужбы нapoдoв
- Первый МГМУ им. И. М. Сеченова (Сеченовский университет)
- Выпуск: Том 99, № 3 (2023)
- Страницы: 23-32
- Раздел: ОБЗОР ЛИТЕРАТУРЫ
- URL: https://bakhtiniada.ru/0042-4609/article/view/131371
- DOI: https://doi.org/10.25208/vdv1400
- ID: 131371
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Аннотация
Экстрамаммарный рак Педжета — медленно растущая кожная внутриэпителиальная аденокарцинома апокринных желез в аногенитальной и подмышечных областях. Заболевание встречается крайне редко, преимущественно у женщин постменопаузального возраста и характеризуется неспецифической клинической картиной, в связи с чем от момента первых клинических признаков до постановки диагноза может пройти 2–10 лет.
Чаще всего поражаются вульва и перианальная зона, при этом клинически заболевание проявляется в виде четко очерченных эритематозных бляшек со вторичными изменениями, такими как шелушение, изъязвление и даже кровотечение.
Дифференциальная диагностика проводится между первичными и вторичными формами экстрамаммарного рака Педжета, кандидозом, контактным дерматитом, болезнью Крона, экземой, эрозивным красным плоским лишаем, гнойным гидраденитом, гистиоцитозом из клеток Лангерханса, склероатрофическим лихеном, псориазом, плоскоклеточной карциномой in situ, амеланотической меланомой и грибовидным микозом.
Лечение в основном включает хирургический компонент, также возможно применение фотодинамической терапии, цитостатических агентов, в зависимости от стадии — системной химиотерапии.
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Ольга Олеговна Емельянова
Московский нaучнo-иccлeдoвaтeльcкий oнкoлoгичecкий инcтитут имeни П. A. Гepцeнa — филиaл Нaциoнaльного медицинского иccлeдoвaтeльcкого цeнтpа paдиoлoгии
Автор, ответственный за переписку.
Email: yemelyanova-olya@list.ru
ORCID iD: 0000-0002-1276-4513
Россия, Москва
Азиз Дильшодович Зикиряходжаев
Московский нaучнo-иccлeдoвaтeльcкий oнкoлoгичecкий инcтитут имeни П. A. Гepцeнa — филиaл Нaциoнaльного медицинского иccлeдoвaтeльcкого цeнтpа paдиoлoгии; Poccийcкий унивepcитeт дpужбы нapoдoв; Первый МГМУ им. И. М. Сеченова (Сеченовский университет)
Email: azizz@mail.ru
ORCID iD: 0000-0001-7141-2502
SPIN-код: 8421-0364
д.м.н.
Россия, Москва; Москва; МоскваЭрик Карлович Сарибекян
Московский нaучнo-иccлeдoвaтeльcкий oнкoлoгичecкий инcтитут имeни П. A. Гepцeнa — филиaл Нaциoнaльного медицинского иccлeдoвaтeльcкого цeнтpа paдиoлoгии
Email: mammolog3@yandex.ru
ORCID iD: 0000-0003-0827-7998
SPIN-код: 3491-0586
д.м.н.
Россия, МоскваЕлена Вячеславовна Филоненко
Московский нaучнo-иccлeдoвaтeльcкий oнкoлoгичecкий инcтитут имeни П. A. Гepцeнa — филиaл Нaциoнaльного медицинского иccлeдoвaтeльcкого цeнтpа paдиoлoгии; Poccийcкий унивepcитeт дpужбы нapoдoв
Email: derkul23@yandex.ru
ORCID iD: 0000-0001-8506-7455
SPIN-код: 6868-9605
д.м.н., профессор
Россия, Москва; МоскваСписок литературы
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