Иммунный патогенез псориаза
- Авторы: Хайрутдинов В.Р.1, Белоусова И.Э.1, Самцов А.В.1
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Учреждения:
- ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
- Выпуск: Том 92, № 4 (2016)
- Страницы: 20-26
- Раздел: КРАТКИЕ СООБЩЕНИЯ
- URL: https://bakhtiniada.ru/0042-4609/article/view/116809
- DOI: https://doi.org/10.25208/0042-4609-2016-92-4-20-26
- ID: 116809
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Полный текст
Аннотация
Представлены современные сведения об иммунных механизмах развития псориаза. Воспаление в коже больных псориазом рассматривается как аутоиммунный процесс, в котором ключевую роль играют сенсибилизированные к кератиноцитам Т-лимфоциты. Одним из наиболее вероятных аутоантигенов, инициирующих иммунное воспаление при псориазе, может являться цитозольная ДНК. Описаны функции отдельных субпопуляций иммунных клеток и эффекты секретируемых ими цитокинов в патогенезе псориаза: дендритных клеток - клеток Лангерганса, плазмацитоидных дендритных клеток, CD11c+ дендритных клеток; Т-лимфоцитов - Т-хелперов 1-го и 17-го типов, цитотоксических Т-лимфоцитов, Т-регуляторных лимфоцитов. Важная роль в развитии рецидивов псориаза отводится формированию в коже больных Т-клеточной памяти и интрадермальной пролиферации Т-лимфоцитов.
Об авторах
В. Р. Хайрутдинов
ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
Автор, ответственный за переписку.
Email: noemail@neicon.ru
Россия
И. Э. Белоусова
ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
Email: noemail@neicon.ru
Россия
А. В. Самцов
ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ
Email: noemail@neicon.ru
Россия
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