Evaluation of the efficacy and safety of combined treatment with methotrexate and a broadband medium-wave phototherapy for psoriasis patients
- Authors: Grigoriyev D.V.1, Vladimirov V.V.2
-
Affiliations:
- MUZ Kolomenskaya Central District Hospital
- FGBOU DPO Institute of Advanced Training at the Federal Medical and Biological Agency of Russia
- Issue: Vol 90, No 6 (2014)
- Pages: 131-135
- Section: CLINICAL PRACTICE GUIDELINES
- URL: https://bakhtiniada.ru/0042-4609/article/view/116702
- DOI: https://doi.org/10.25208/0042-4609-2014-90-6-131-135
- ID: 116702
Cite item
Full Text
Abstract
Goal. To evaluate the efficacy and safety of combined treatment with methotrexate and a broadband medium-wave phototherapy for psoriasis patients. Materials and methods. As many as 365 psoriasis patients underwent examination and treatment. The patients were divided into three groups by the treatment method. The first group of patients received a broadband medium-wave phototherapy, the second group received treatment with methotrexate, and the third group received combined treatment with methotrexate and a broadband medium-wave phototherapy. Results. Combined treatment with a broadband medium-wave phototherapy and methotrexate turned out to be more efficient than a monotherapy with methotrexate or a broadband medium-wave phototherapy. The administration of a combined therapy enhances the efficacy of treatment for psoriasis patients due to the reduction of cumulative doses of ultraviolet irradiation and methotrexate. In addition, it was revealed that a broadband medium-wave phototherapy does not enhance typical side effects observed during the treatment with methotrexate.
About the authors
D. V. Grigoriyev
MUZ Kolomenskaya Central District Hospital
Author for correspondence.
Email: intermedimport@mail.ru
Russian Federation
V. V. Vladimirov
FGBOU DPO Institute of Advanced Training at the Federal Medical and Biological Agency of Russia
Email: intermedimport@mail.ru
Russian Federation
References
- Общая заболеваемость всего населения России в 2012 году. Статистические материалы. Часть II. Министерство здравоохранения Российской Федерации. Департамент анализа, прогноза и инновационного развития здравоохранения ФГБУ «Центральный научно-исследовательский институт организации и информатизации здравоохранения» Минздрава. Москва 2013; 109, 111, 113
- Paul B.S., Momtax K., Stern R.S., Arndt K.A., Parrish J.A. Combined methotrexate-ultraviolet B therapy in the treatment of psoriasis. J Am Acad Dermatol 1982; 7: 758-62.
- Zanolli Michael. Phototherapy arsenal in the treatment of psoriasis. Dermatologic Clinics 2004; 22: 397-406.
- Clinical Dermatology /fifth edition/ Thomas P. Habif Mosby Elsevier 2010; 284-285.
- Braun-Falco's Dermatology 3rd edition Burgdorf W.H.C.; Plewig G.; Wolff H.H: Springer 2008; 513-518, 1596-1597.
- Rook's Textbook of Dermatology, 4 Volume Set - Print and Online Package Wiley-Blackwell 2010; 898-906.
- Dermatology E-Book, 3rd Edition By Jean L. Bolognia M.D., Joseph L. Jorizzo M.D. and Julie V. Schaffer M.D. Imprint: Saunders Copyright: 2012; 129-130, 2016-2017.
- Fitzpatrick's Dermatology In General Medicine (2-Volume Set) seventh edition McGraw-Hill 2007; 185- 187, 2243-2249.
- Григорьев Д.В., Владимиров В.В. Широкополосное средневолновое ультрафиолетовое излучение в сочетании с метотрексатом в терапии больных псориазом. V Всероссийский конгресс дерматовенерологов и косметологов Тезисы научных работ Казань, 2013, с. 16
- Grigor'ev D.V. Kombinirovannoe lechenie psoriaza shirokopolosnym srednevolnovym ul'trafioletovym izlucheniem i metotreksatom. Russkij medicinskij zhurnal, 2013
- Григорьев Д.В. Комбинированное лечение псориаза широкополосным средневолновым ультрафиолетовым излучением и метотрексатом. Рус мед журн, 2013, (8): 413-416
- Владимиров В.В. Роль классификации фототипов кожи при выборе рациональной фототерапии. Вестник дерматологии и венерологии 2009; (4): 65-67
Supplementary files
