电邮这篇文章 Features of cellular structure of the induced sputum and profile of cytokines at sintropiya of bronchial asthma and obesity at young patients
- 作者: Soloveva IA1,2, Sobko EA1,2, Demko IV1,2, Kraposhina AY.1, Loktionova MM1, Gordeeva NV1,2
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隶属关系:
- Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetsky
- Regional Clinical Hospital
- 期: 卷 90, 编号 3 (2018)
- 页面: 25-32
- 栏目: Editorial
- URL: https://bakhtiniada.ru/0040-3660/article/view/32722
- DOI: https://doi.org/10.26442/terarkh201890325-32
- ID: 32722
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Aim. To estimate changes of cellular structure of the induced sputum at young patients with bronchial asthma at interrelations with BMI and level of cytokines in blood plasma. Materials and methods. 164 patients with bronchial asthma were divided into 2 groups taking into BMI: the 1st group included patients with bronchial asthma and BMI from 18 to 25 kg/m2, patients with bronchial asthma and BMI from 30 to 40 kg/m2 entered into the 2nd group. The group of control was made by 40 almost healthy volunteers. Estimated existence of excess weight and defined obesity degree according to recommendations of World Health Organization. Studied the level of control of bronchial asthma, cellular structure of the induced sputum, the IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-17, TNF-α, INF-γ levels in plasma of peripheral blood. Results. There are presented the results of the research of cellular profile of the induced sputum and profile of cytokines at patients with bronchial asthma depending on BMI and severity of the disease. The received results testify to prevalence of eosinophilic type of an inflammation in the group of patients with BMI less than 25 kg/m2 whereas at patients mainly paucigranulation inflammation decided on obesity. The highest content of the Il-17 was registered at patients with bronchial asthma and obesity as in comparison with indicators of patients with normal BMI, and with almost healthy that, perhaps, is the reason of low effect of steroid therapy at these patients. Conclusion. Endotype assessment before basic antiinflammatory therapy at patients with the first time diagnosed bronchial asthma, will be able to help with selection of the most optimum treatment to each specific patient.
作者简介
I Soloveva
Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetsky; Regional Clinical Hospital
Email: solovieva.irina@inbox.ru
к.м.н., доцент каф. внутренних болезней №2 с курсом ПО, врач-аллерголог Краевого ГБУЗ «Краевая клиническая больница» Krasnoyarsk, Russia
E Sobko
Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetsky; Regional Clinical Hospitalм.н., доцент каф. внутренних болезней №2 с курсом ПО; зав. отд-нием аллергологии Krasnoyarsk, Russia
I Demko
Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetsky; Regional Clinical Hospitalд.м.н., проф., зав. каф. внутренних болезней №2 с курсом ПО Krasnoyarsk, Russia
A Kraposhina
Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetskyк.м.н., доцент каф. внутренних болезней №2 с курсом ПО Krasnoyarsk, Russia
M Loktionova
Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetskyклин. ординатор каф. внутренних болезней №2 с курсом ПО Krasnoyarsk, Russia
N Gordeeva
Krasnoyarsk state medical university named after prof. V.F. Voino-Yasenetsky; Regional Clinical Hospitalк.м.н., доцент каф. внутренних болезней №2 с курсом ПО; врач-пульмонолог Краевого ГБУЗ «Краевая клиническая больница» Krasnoyarsk, Russia
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