Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report

The article discusses intra-articular injections of polynucleotides (PN) for joint preconditioning before the injections of high-molecular-weight hyaluronic acid (HA) in the context of treating osteoarthritis (OA). OA is still one of the significant problems that affect patients' quality of life, causing pain and limiting joint mobility. Conventional therapy, including HA injections, has shown encouraging results, especially using cross-linked HA being studied for its long-lasting therapeutic effect. However, in practice, the lack of a proper response to treatment in patients with active synovitis determines the need for new methods of joint preconditioning for injection. The article discusses approaches to preconditioning, including PN use, to improve treatment outcomes. PN-based agents potentially promote tissue repair and improve the perception of HA injections. The results of preliminary studies emphasize the importance of this strategy in the practice of orthopedic and rheumatological care, indicating the possibility of significantly improving the quality of life of OA patients through an integrated approach to intra-articular therapy.