Experimental Modeling of Formation of the Basic Mineral Phases of Calcifications

Abstract

Calcium phosphate phase formation was studied under process conditions involving human blood plasma. Calcium phosphate was synthesized with variable supersaturation (S) and experimental time. It was found that a non-stoichiometric hydrated carbonated hydroxyapatite, identical in the composition to calcifications in humans, is formed under the experimental conditions. The highest amount of carbonate ions (5.54 wt %) in the solid phase corresponds to the apatite synthesized at S = 50 for 10 weeks. The dissolution rate of solid phases was determined by mathematical processing of the obtained kinetic curves; this can be used to find compounds able to stop the development of vascular calcinosis.