The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

Diagnostic pilot monitoring of the groups of healthy patients and patients with colorectal cancer (CRC) at different stages of the disease was carried out using Raman spectroscopy (RS) and measuring the state of polarized light near the conditions of observation of surface plasmon resonance (SPR). The reaction of the blood serum antigens with antibodies to serum M2 pyruvate kinase (M2-PK) nears the conditions of observation of SPR was used for diagnosing; for this, the Ellipse-SPEC spectral ellipsometric complex created at the Rzhanov Institute of Semiconductor Physics (Siberian Branch, Russian Academy of Sciences) and having a high sensitivity, accuracy, and nondestructive nature of the effect on the studied sample, was used in the work. The peak intensities at 1005, 1157, and 1520 cm–1 in Raman spectra in CRC patients as compared with healthy individuals (as well as the intensity of surface plasmon resonance) were significantly lower, correlating with the stage of the disease and the presence of metastases; this allows to consider these optical methods for studying the blood serum as promising diagnostic approaches in diagnosis CRC, including in the early stages of the disease.

作者简介

V. Kruchinin

Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630090

M. Kruchinina

Research Institute of Internal and Preventive Medicine,
Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch,
Russian Academy of Sciences; Novosibirsk State Medical University

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630089; Novosibirsk, 630091

Ya. Prudnikova

Research Institute of Internal and Preventive Medicine,
Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch,
Russian Academy of Sciences

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630089

E. Spesivtsev

Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630090

S. Rykhlitskii

Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630090

V. Volodin

Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090

S. Shekhovtsov

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630090

S. Pel’tek

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: vladd.kruch@yandex.ru
俄罗斯联邦, Novosibirsk, 630090

补充文件

附件文件
动作
1. JATS XML

版权所有 © Pleiades Publishing, Ltd., 2019