Quantification of Hexamethylenediamide Bis(N-Monosuccinyl-L-Glutamyl-L-Lysine) in Blood Plasma by HPLC–MS


Дәйексөз келтіру

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Аннотация

The quantitative determination of a new compound hexamethylenediamide bis(N-monosuccinyl-L-glutamyl-L-lysine) (GK-2) in rat blood plasma is developed and validated by the HPLC–MS technique. The method is linear in the range of 10 to 1000 ng/mL. It is shown that 81.62% of GK-2 is recovered from the plasma. The lower limit of its quantification was 10 ng/mL.

Авторлар туралы

A. Litvin

Zakusov Research Institute of Pharmacology

Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

G. Kolyvanov

Zakusov Research Institute of Pharmacology

Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

E. Blynskaya

Zakusov Research Institute of Pharmacology

Хат алмасуға жауапты Автор.
Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

O. Grybakina

Zakusov Research Institute of Pharmacology

Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

P. Bochkov

Zakusov Research Institute of Pharmacology

Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

R. Shevchenko

Zakusov Research Institute of Pharmacology

Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

V. Zherdev

Zakusov Research Institute of Pharmacology

Email: litbiopharm@yandex.ru
Ресей, Moscow, 125315

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