Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds


Дәйексөз келтіру

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Аннотация

The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (Ssp = 283 ± 5 m2/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (Ssp = 289 ± 5 m2/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds.

Авторлар туралы

A. Solomatin

Department of Chemistry; Ryazan State Medical University

Хат алмасуға жауапты Автор.
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991; Ryazan, 390026

R. Yakovlev

Ryazan State Medical University; Vernadsky Institute of Geochemistry and Analytical Chemistry

Email: solo-msu@yandex.ru
Ресей, Ryazan, 390026; Moscow, 119991

N. Leonidov

Ryazan State Medical University

Email: solo-msu@yandex.ru
Ресей, Ryazan, 390026

G. Badun

Department of Chemistry

Email: solo-msu@yandex.ru
Ресей, Moscow, 119991

M. Chernysheva

Department of Chemistry

Email: solo-msu@yandex.ru
Ресей, Moscow, 119991

I. Kulakova

Department of Chemistry

Email: solo-msu@yandex.ru
Ресей, Moscow, 119991

A. Stavrianidi

Department of Chemistry

Email: solo-msu@yandex.ru
Ресей, Moscow, 119991

O. Shlyakhtin

Department of Chemistry

Email: solo-msu@yandex.ru
Ресей, Moscow, 119991

G. Lisichkin

Department of Chemistry

Email: solo-msu@yandex.ru
Ресей, Moscow, 119991

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