Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds
- Авторлар: Solomatin A.S.1,2, Yakovlev R.Y.2,3, Leonidov N.B.2, Badun G.A.1, Chernysheva M.G.1, Kulakova I.I.1, Stavrianidi A.N.1, Shlyakhtin O.A.1, Lisichkin G.V.1
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Мекемелер:
- Department of Chemistry
- Ryazan State Medical University
- Vernadsky Institute of Geochemistry and Analytical Chemistry
- Шығарылым: Том 73, № 3 (2018)
- Беттер: 91-98
- Бөлім: Article
- URL: https://bakhtiniada.ru/0027-1314/article/view/163642
- DOI: https://doi.org/10.3103/S0027131418030082
- ID: 163642
Дәйексөз келтіру
Аннотация
The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (Ssp = 283 ± 5 m2/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (Ssp = 289 ± 5 m2/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds.
Негізгі сөздер
Авторлар туралы
A. Solomatin
Department of Chemistry; Ryazan State Medical University
Хат алмасуға жауапты Автор.
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991; Ryazan, 390026
R. Yakovlev
Ryazan State Medical University; Vernadsky Institute of Geochemistry and Analytical Chemistry
Email: solo-msu@yandex.ru
Ресей, Ryazan, 390026; Moscow, 119991
N. Leonidov
Ryazan State Medical University
Email: solo-msu@yandex.ru
Ресей, Ryazan, 390026
G. Badun
Department of Chemistry
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991
M. Chernysheva
Department of Chemistry
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991
I. Kulakova
Department of Chemistry
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991
A. Stavrianidi
Department of Chemistry
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991
O. Shlyakhtin
Department of Chemistry
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991
G. Lisichkin
Department of Chemistry
Email: solo-msu@yandex.ru
Ресей, Moscow, 119991
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