Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds

Abstract

The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (S_sp = 283 ± 5 m²/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (S_sp = 289 ± 5 m²/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds.