Мақаланы E-mail арқылы жіберу The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology
- Авторлар: Nikolskaya I.I.1, Beznos O.V.2, Eltsov A.I.1, Gachok I.V.1, Chesnokova N.B.2, Varlamov V.P.3, Kost O.A.1
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Мекемелер:
- Department of Chemistry
- Helmholtz Moscow Research Institute of Eye Diseases
- Federal Research Center “Fundamentals of Biotechnology,”
- Шығарылым: Том 73, № 2 (2018)
- Беттер: 85-89
- Бөлім: Article
- URL: https://bakhtiniada.ru/0027-1314/article/view/163638
- DOI: https://doi.org/10.3103/S0027131418020116
- ID: 163638
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Аннотация
Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Cax(PO4)y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure.
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Авторлар туралы
I. Nikolskaya
Department of Chemistry
Email: olga.a.kost@gmail.com
Ресей, Moscow, 119991
O. Beznos
Helmholtz Moscow Research Institute of Eye Diseases
Email: olga.a.kost@gmail.com
Ресей, Moscow, 105062
A. Eltsov
Department of Chemistry
Email: olga.a.kost@gmail.com
Ресей, Moscow, 119991
I. Gachok
Department of Chemistry
Email: olga.a.kost@gmail.com
Ресей, Moscow, 119991
N. Chesnokova
Helmholtz Moscow Research Institute of Eye Diseases
Email: olga.a.kost@gmail.com
Ресей, Moscow, 105062
V. Varlamov
Federal Research Center “Fundamentals of Biotechnology,”
Email: olga.a.kost@gmail.com
Ресей, Moscow, 119071
O. Kost
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: olga.a.kost@gmail.com
Ресей, Moscow, 119991
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