Email this article The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology
- Authors: Nikolskaya I.I.1, Beznos O.V.2, Eltsov A.I.1, Gachok I.V.1, Chesnokova N.B.2, Varlamov V.P.3, Kost O.A.1
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Affiliations:
- Department of Chemistry
- Helmholtz Moscow Research Institute of Eye Diseases
- Federal Research Center “Fundamentals of Biotechnology,”
- Issue: Vol 73, No 2 (2018)
- Pages: 85-89
- Section: Article
- URL: https://bakhtiniada.ru/0027-1314/article/view/163638
- DOI: https://doi.org/10.3103/S0027131418020116
- ID: 163638
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Abstract
Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Cax(PO4)y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure.
About the authors
I. I. Nikolskaya
Department of Chemistry
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 119991
O. V. Beznos
Helmholtz Moscow Research Institute of Eye Diseases
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 105062
A. I. Eltsov
Department of Chemistry
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 119991
I. V. Gachok
Department of Chemistry
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 119991
N. B. Chesnokova
Helmholtz Moscow Research Institute of Eye Diseases
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 105062
V. P. Varlamov
Federal Research Center “Fundamentals of Biotechnology,”
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 119071
O. A. Kost
Department of Chemistry
Author for correspondence.
Email: olga.a.kost@gmail.com
Russian Federation, Moscow, 119991
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