Email this article The relationship between NO-synthase inhibitory activity of N,S-containing heterocycles and their radioprotective and antileukemic properties
- Authors: Orlova M.A.1,2, Trofimova T.P.1,2, Nikulin S.V.2,3, Orlov A.P.1,4
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Affiliations:
- Department of Chemistry
- Rogachev Federal Scientific Clinical Centre of Pediatric Hematology
- Moscow Institute of Physics and Technology
- Scientific Centre for Expertise of Medical Products
- Issue: Vol 71, No 4 (2016)
- Pages: 258-262
- Section: Article
- URL: https://bakhtiniada.ru/0027-1314/article/view/163292
- DOI: https://doi.org/10.3103/S0027131416040052
- ID: 163292
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Abstract
The effect of NO-synthase (NOS) activator and inhibitors on leukemic cell lines HL-60, K-562, and MOLT-4 and bone marrow cells of untreated patients diagnosed with B-cell acute lymphoblastic leukemia compared with lymphocytes from healthy donors is examined. The obtained data on the relationships between the radioprotective, NOS inhibitory, and cytotoxic properties of a number of thiazine, thiazoline, and thiourea derivatives indicates their potential for use as agents for complex radio- and chemotherapy.
About the authors
M. A. Orlova
Department of Chemistry; Rogachev Federal Scientific Clinical Centre of Pediatric Hematology
Author for correspondence.
Email: orlova.radiochem@mail.ru
Russian Federation, Moscow; Moscow
T. P. Trofimova
Department of Chemistry; Rogachev Federal Scientific Clinical Centre of Pediatric Hematology
Email: orlova.radiochem@mail.ru
Russian Federation, Moscow; Moscow
S. V. Nikulin
Rogachev Federal Scientific Clinical Centre of Pediatric Hematology; Moscow Institute of Physics and Technology
Email: orlova.radiochem@mail.ru
Russian Federation, Moscow; Moscow
A. P. Orlov
Department of Chemistry; Scientific Centre for Expertise of Medical Products
Email: orlova.radiochem@mail.ru
Russian Federation, Moscow; Moscow
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