Synthesis of Amphiphilic Peptidomimetics Based on the Aliphatic Derivatives of Natural Amino Acids


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Abstract

Abstract—The paper describes the production of a number of lipoamino acid derivatives based on L-serine, L-ornithine, and L-lysine with potential antibacterial activity. The designed synthesis schemes are distinguished by the simplicity and versatility of the approach used. This allows us to use them to obtain a series of samples in preparative quantities required to perform the subsequent physico-chemical and biochemical studies.

About the authors

Z. G. Denieva

MIREA—Russian Technological University (Lomonosov Institute of Fine Chemical Technology)

Author for correspondence.
Email: c-221@yandex.ru
Russian Federation, Moscow, 119571

N. A. Romanova

MIREA—Russian Technological University (Lomonosov Institute of Fine Chemical Technology)

Email: c-221@yandex.ru
Russian Federation, Moscow, 119571

T. G. Bodrova

MIREA—Russian Technological University (Lomonosov Institute of Fine Chemical Technology)

Email: c-221@yandex.ru
Russian Federation, Moscow, 119571

U. A. Budanova

MIREA—Russian Technological University (Lomonosov Institute of Fine Chemical Technology)

Email: c-221@yandex.ru
Russian Federation, Moscow, 119571

Yu. L. Sebyakin

MIREA—Russian Technological University (Lomonosov Institute of Fine Chemical Technology)

Email: c-221@yandex.ru
Russian Federation, Moscow, 119571

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