Comparative Pharmacokinetics and Relative Bioavailability of a New Anxiolytic GML-1 in Tablet Form

Resumo

An open, single, crossover, pharmacokinetic study of GML-1 (dose 50 mg/kg) in rabbits after its oral administration in tablets and alone as a substance is carried out. The following pharmacokinetic parameters are calculated: the maximum concentration of GML-1 in blood plasma (C_max) of rabbits, the time required to reach C_max, the area under the concentration-time curve, the half-time of GML-1, and the relative bioavailability. The GML-1 concentration is detected with the use of the HPLC-MS (ion trap) by the daughter ions. The relative bioavailability of GML-1 in tablets is 101.72 ± 19.96% in comparison to the substance.