Quantum Chemical Study of Regularities of Electrophilic Substitution in the Synthesis of Pyrroloquinolines

Abstract

It has been shown that the cyclization of the indolylenaminoketones prepared from substituted 5-aminoindoles, which is carried out according to the mechanism of electrophilic substitution, is an orbitally controlled interaction. The formation of pyrroloquinolines with a linear or angular structure is determined by the values of the electronic populations of the frontier orbitals of the interacting atoms.