Studying Dependences Between the Chemotype Structure of Some Natural Compounds and the Spectrum of Their Targeted Activities Correlated with the Hypoglycemic Effect

P. M. Vasilyev; O. A. Luzina; D. A. Babkov; D. T. Appazova; N. F. Salakhutdinov; A. A. Spasov

doi:10.1134/S0022476619110179

Studying Dependences Between the Chemotype Structure of Some Natural Compounds and the Spectrum of Their Targeted Activities Correlated with the Hypoglycemic Effect

Авторы: Vasilyev P.M.¹, Luzina O.A.², Babkov D.A.¹, Appazova D.T.¹, Salakhutdinov N.F.²^,3, Spasov A.A.¹
Учреждения:
1. Volgograd State Medical University
2. Vorozhtsov Institute of Organic Chemistry, Siberian Branch
3. Novosibirsk State University
Выпуск: Том 60, № 11 (2019)
Страницы: 1827-1832
Раздел: Article
URL: https://bakhtiniada.ru/0022-4766/article/view/162228
DOI: https://doi.org/10.1134/S0022476619110179
ID: 162228

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Аннотация

The method of similarity to standards is used to calculate the spectrum of targeted hypoglycemic activities of a series of natural compounds of terpenoid and polyphenol classes. Some compounds are shown to be promising multitargeted hypoglycemic agents. Primary action targets are identified.

Ключевые слова

natural compounds, terpenoids, polyphenols, hypoglycemic activity, in silico, QSAR, Microcosm BioS, multitargeted action, prediction of the targeted activity spectrum