Parallel Computations in the Development of Thermostable Lipase Mutants
- Авторлар: Kondratyev M.S.1, Kabanov A.V.1, Samchenko A.A.1, Komarov V.M.1, Khechinashvili N.N.1
-
Мекемелер:
- Institute of Cell Biophysics
- Шығарылым: Том 59, № 8 (2018)
- Беттер: 1974-1979
- Бөлім: Article
- URL: https://bakhtiniada.ru/0022-4766/article/view/161819
- DOI: https://doi.org/10.1134/S0022476618080292
- ID: 161819
Дәйексөз келтіру
Аннотация
The advanced high performance computing methods are used to study the stability and conformational dynamics of the bacterial enzyme lipase LipA, its mutants, and the close homologous enzyme CLE whose substrate is polylactic acid-based plastics. From the analysis of the GPU molecular dynamics of native lipases and their mutants the amino acid residues whose point substitutions can markedly improve the thermostability of the enzymes under study without deteriorating their activity are determined.
Негізгі сөздер
Авторлар туралы
M. Kondratyev
Institute of Cell Biophysics
Хат алмасуға жауапты Автор.
Email: ma-ko@bk.ru
Ресей, Pushchino
A. Kabanov
Institute of Cell Biophysics
Email: ma-ko@bk.ru
Ресей, Pushchino
A. Samchenko
Institute of Cell Biophysics
Email: ma-ko@bk.ru
Ресей, Pushchino
V. Komarov
Institute of Cell Biophysics
Email: ma-ko@bk.ru
Ресей, Pushchino
N. Khechinashvili
Institute of Cell Biophysics
Email: ma-ko@bk.ru
Ресей, Pushchino
Қосымша файлдар
