Interaction of 1,2,4-Triazole Nitro Derivatives with α-Hydroxyethyl Radicals: A Steady-State Radiolysis Study

Resumo

A series of 1,2,4-triazole nitro and dinitro derivatives has been synthesized. The interaction of the obtained compounds with carbon-centered radicals formed during the radiolysis of deaerated ethanol was studied by the steady-state radiolysis method. It has been established that 1,2,4-triazole slightly changes the ratio of the radiation-chemical yields of deaerated ethanol radiolysis products in favor of acetaldehyde, while the nitro derivatives of this nitrogen-containing heterocyclic compound quantitatively oxidize α-hydroxyethyl radicals. It was shown that the introduction of the second nitro group into the 1,2,4-triazole cycle does not result in substantial changes in the efficiency of the interaction of the tested substances with α-hydroxyethyl radicals. A mechanism has been proposed for the formation of the identified by liquid chromatography-mass spectrometry final molecular products of the radiation-induced transformations of the radiation sensitizer Sanazol in deaerated ethanol.