Autoradiolytic Decomposition of Radiopharmaceutical 2-[18F]Fluorodeoxyglucose
- 作者: Brinkevich S.D.1, Tugai O.V.1, Nevzorov D.I.2
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隶属关系:
- Republican Scientific and Practical Center of Oncology and Medical Radiology
- Blokhin National Medical Research Center of Oncology
- 期: 卷 53, 编号 4 (2019)
- 页面: 300-308
- 栏目: Radiation Chemistry
- URL: https://bakhtiniada.ru/0018-1439/article/view/157695
- DOI: https://doi.org/10.1134/S0018143919040040
- ID: 157695
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详细
The kinetics of autoradiolytic degradation of the radiopharmaceutical drug 2-[18F]fluorodeoxyglucose ([18F]FDG) in an air-saturated normal saline solution with initial activity concentrations of 1 and 2 GBq/mL has been studied. It has been established that the only radioactive product of radiation-induced transformations of [18F]FDG is [18F]fluoride, whose contribution in the total activity of the radiopharmaceutical increases with storage. It has been shown that an increase in the initial activity concentration of the radiopharmaceutical or a decrease in the concentration of ethanol in it leads to the enhancement of autoradiolytic degradation of [18F]FDG. However, an increase in the storage temperature of the solutions from 25 to 40°C does not affect the rate of radiation-induced dehalogenation of [18F]FDG.
作者简介
S. Brinkevich
Republican Scientific and Practical Center of Oncology and Medical Radiology
编辑信件的主要联系方式.
Email: BrinkevichSD@bsu.by
白俄罗斯, Lesnoi, Minsk oblast, 223040
O. Tugai
Republican Scientific and Practical Center of Oncology and Medical Radiology
Email: BrinkevichSD@bsu.by
白俄罗斯, Lesnoi, Minsk oblast, 223040
D. Nevzorov
Blokhin National Medical Research Center of Oncology
Email: BrinkevichSD@bsu.by
俄罗斯联邦, Moscow, 115478
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