Autoradiolytic Decomposition of Radiopharmaceutical 2-[18F]Fluorodeoxyglucose


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The kinetics of autoradiolytic degradation of the radiopharmaceutical drug 2-[18F]fluorodeoxyglucose ([18F]FDG) in an air-saturated normal saline solution with initial activity concentrations of 1 and 2 GBq/mL has been studied. It has been established that the only radioactive product of radiation-induced transformations of [18F]FDG is [18F]fluoride, whose contribution in the total activity of the radiopharmaceutical increases with storage. It has been shown that an increase in the initial activity concentration of the radiopharmaceutical or a decrease in the concentration of ethanol in it leads to the enhancement of autoradiolytic degradation of [18F]FDG. However, an increase in the storage temperature of the solutions from 25 to 40°C does not affect the rate of radiation-induced dehalogenation of [18F]FDG.

作者简介

S. Brinkevich

Republican Scientific and Practical Center of Oncology and Medical Radiology

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Email: BrinkevichSD@bsu.by
白俄罗斯, Lesnoi, Minsk oblast, 223040

O. Tugai

Republican Scientific and Practical Center of Oncology and Medical Radiology

Email: BrinkevichSD@bsu.by
白俄罗斯, Lesnoi, Minsk oblast, 223040

D. Nevzorov

Blokhin National Medical Research Center of Oncology

Email: BrinkevichSD@bsu.by
俄罗斯联邦, Moscow, 115478

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