Email this article Deuterium–hydrogen exchange reactions in peptides and polyatomic organic compounds, as studied on an ion cyclotron resonance mass spectrometer equipped with an ion trap with dynamic harmonization
- Authors: Kostyukevich Y.I.1,2,3, Kharybin O.N.1, Kononikhin A.S.1,4,3, Popov I.A.1,4,3, Nikolaev E.N.1,4,2,3
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Affiliations:
- Talrose Institute of Energy Problems of Chemical Physics
- Skolkovo Institute of Science and Technology
- Moscow Institute of Physics and Technology (State University)
- Emanuel Institute of Biochemical Physics
- Issue: Vol 50, No 3 (2016)
- Pages: 165-170
- Section: General Aspects of High Energy Chemistry
- URL: https://bakhtiniada.ru/0018-1439/article/view/156949
- DOI: https://doi.org/10.1134/S0018143916030097
- ID: 156949
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Abstract
The ultrahigh-resolution mass spectra of a substance P peptide labeled with deuterium have been obtained. The use of an ion trap with dynamic harmonization has made it possible to resolve the hyperfine isotopic structure of peaks and to reliably distinguish the hydrogen isotopes from the isotopes of carbon in the composition of the test molecules. The deuterium–hydrogen exchange reaction of humic acids has been performed in a gas phase, and it has been shown that the resolving power attained is sufficient for reliable interpretation of the results.
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About the authors
Yu. I. Kostyukevich
Talrose Institute of Energy Problems of Chemical Physics; Skolkovo Institute of Science and Technology; Moscow Institute of Physics and Technology (State University)
Email: ennikolaev@rambler.ru
Russian Federation, Leninskii pr. 38, Moscow, 119334; ul. Nobelya 3, Skolkovo, Moscow oblast, 143025; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
O. N. Kharybin
Talrose Institute of Energy Problems of Chemical Physics
Email: ennikolaev@rambler.ru
Russian Federation, Leninskii pr. 38, Moscow, 119334
A. S. Kononikhin
Talrose Institute of Energy Problems of Chemical Physics; Emanuel Institute of Biochemical Physics; Moscow Institute of Physics and Technology (State University)
Email: ennikolaev@rambler.ru
Russian Federation, Leninskii pr. 38, Moscow, 119334; ul. Kosygina 4, Moscow, 119334; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
I. A. Popov
Talrose Institute of Energy Problems of Chemical Physics; Emanuel Institute of Biochemical Physics; Moscow Institute of Physics and Technology (State University)
Email: ennikolaev@rambler.ru
Russian Federation, Leninskii pr. 38, Moscow, 119334; ul. Kosygina 4, Moscow, 119334; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
E. N. Nikolaev
Talrose Institute of Energy Problems of Chemical Physics; Emanuel Institute of Biochemical Physics; Skolkovo Institute of Science and Technology; Moscow Institute of Physics and Technology (State University)
Author for correspondence.
Email: ennikolaev@rambler.ru
Russian Federation, Leninskii pr. 38, Moscow, 119334; ul. Kosygina 4, Moscow, 119334; ul. Nobelya 3, Skolkovo, Moscow oblast, 143025; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
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