Email this article Mechanisms of Drug Resistance of Acute Myeloid Leukemia Cells in Three-Dimensional High-Density Cultures: A Study of Intracellular Accumulation of Chemotherapeutic Drugs
- Authors: Kobyakova M.I1, Lomovskaya Y.V1, Fadeev R.S1
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Affiliations:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Issue: Vol 70, No 4 (2025)
- Pages: 736–741
- Section: Cell biophysics
- URL: https://bakhtiniada.ru/0006-3029/article/view/306899
- DOI: https://doi.org/10.31857/S0006302925040125
- EDN: https://elibrary.ru/LKXJXU
- ID: 306899
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Abstract
Intracellular accumulation of chemotherapeutic drugs in resistant cells of acute myeloid leukemia cultured in a three-dimensional high-density culture was studied. It was shown that neither the dense arrangement of cells, nor the main ABC family transporter proteins most likely affect the increase in drug resistance of acute myeloid leukemia cells in a three-dimensional high-density cell culture. These data indicate the involvement of other mechanisms in increasing drug resistance in three-dimensional high-density cell cultures of acute myeloid leukemia.
About the authors
M. I Kobyakova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: kobyakovami@gmail.com
Pushchino, Moscow Region, Russia
Y. V Lomovskaya
Institute of Theoretical and Experimental Biophysics, Russian Academy of SciencesPushchino, Moscow Region, Russia
R. S Fadeev
Institute of Theoretical and Experimental Biophysics, Russian Academy of SciencesPushchino, Moscow Region, Russia
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