Clinical and epidemiological features of papillomavirus infection manifestations on the example of cervical cancer and genital warts
- 作者: Briko N.I.1,2, Sekacheva M.I.1, Lopukhov P.D.1, Kobzev G.S.1, Kaprin A.D.3, Novikova E.G.3, Trushina O.I.3, Khaldin A.A.4, Maleev V.V.2
-
隶属关系:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Central Research Institute for Epidemiology
- P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology
- Moscow Scientifi c and Practical Center of Dermato-Venereology and Cosmetology
- 期: 卷 75, 编号 1 (2020)
- 页面: 77-82
- 栏目: EPIDEMIOLOGY: CURRENT ISSUES
- URL: https://bakhtiniada.ru/vramn/article/view/125747
- DOI: https://doi.org/10.15690/vramn1212
- ID: 125747
如何引用文章
全文:
详细
Background: Cervical cancer and genital warts (GWs) are some of the most common manifestations of human papillomavirus infection (HPV). These lesions cause significant damage to the reproductive health of the population, which leads to increased attention to the prevention of HPV infection among various population groups.
Aims: To determine the clinical and epidemiological features of the HPV manifestations by the example of cervical cancer and genital warts.
Methods: A retrospective analysis of anamnestic information of 115 women with an established diagnosis of cervical cancer and 177 patients with an established diagnosis of GWs was performed. The clinical and epidemiological characteristics of patients with diagnoses of GWs and cervical cancer were based on the development of outpatient admission cards and inpatient histories, as well as test data for HPV.
Results: HPV 16 was the most common HPV type among patients with GWs and cervical cancer ― it was detected in 37.6% of cases. Also the most frequently encountered: HPV 6/18/11/31/51/52. In 43.2% cases of HPV detection, two or more types were detected at once, the most common combinations: HPV16 and HPV18, HPV6 and HPV16, HPV6 and HPV11. Analysis of the frequency of screening for cervical cancer and visits to the gynecologist for 5 years before establishing the diagnosis showed that among those who did not screen for cervical cancer, the risk of diagnosing stage II–IV was 5.2 times higher than among individuals who underwent cervical screening 2 years ago, or once a year for the last five years. Among patients with GWs who had 2 or more sexual partners for 1 year, 13.5% of patients regularly used barrier contraception methods (condoms) during sexual contact, not regularly ― 61.5%, did not use them at all ― 25.0%.
Conclusions: Identifying the clinical and epidemiological features of HPV infection should contribute to the development of new and optimize existing prevention programs for a wide range of HPV-associated diseases.
关键词
作者简介
Nikolay Briko
I.M. Sechenov First Moscow State Medical University (Sechenov University); Central Research Institute for Epidemiology
Email: nbrico@mail.ru
ORCID iD: 0000-0002-6446-2744
SPIN 代码: 2992-6915
Scopus 作者 ID: 7004344976
MD, PhD, Professor
俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992; 3A, Novogireyevskaya street, Moscow, 111123Marina Sekacheva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: sekach_rab@mail.ru
ORCID iD: 0000-0003-0015-7094
SPIN 代码: 4801-3742
Scopus 作者 ID: 24342526600
MD, PhD, Professor
俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992Platon Lopukhov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: PL2211@yandex.ru
ORCID iD: 0000-0002-0872-2214
SPIN 代码: 1250-6839
Scopus 作者 ID: 57191340780
Researcher ID: S-8582-2017
MD, PhD
俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992Gleb Kobzev
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: glebk09@mail.ru
ORCID iD: 0000-0002-1772-6401
SPIN 代码: 9969-4457
resident of the department of epidemiology and evidence-based medicine
俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992Andrey Kaprin
P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology
Email: mnioi@mail.ru
ORCID iD: 0000-0001-8784-8415
SPIN 代码: 1759-8101
Scopus 作者 ID: 6602709853
MD, PhD, Professor
俄罗斯联邦, 3, 2 Botkinskii ave., Moscow, 125284Elena Novikova
P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology
Email: mnioi@mail.ru
ORCID iD: 0000-0003-2768-5698
SPIN 代码: 2143-9975
Scopus 作者 ID: 7102446296
MD, PhD, Professor
俄罗斯联邦, 3, 2 Botkinskii ave., Moscow, 125284Olga Trushina
P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology
Email: o.trushina@list.ru
ORCID iD: 0000-0003-3462-333X
SPIN 代码: 9885-3814
Scopus 作者 ID: 6506506500
MD, PhD
俄罗斯联邦, 3, 2 Botkinskii ave., Moscow, 125284Aleksey Khaldin
Moscow Scientifi c and Practical Center of Dermato-Venereology and Cosmetology
Email: khaldinderma@yandex.ru
ORCID iD: 0000-0002-3855-1655
SPIN 代码: 4640-1950
Scopus 作者 ID: 7801322925
MD, PhD, Professor
俄罗斯联邦, 20, Seleznevskaya str., Moscow, 127473Viktor Maleev
Central Research Institute for Epidemiology
Email: crie@pcr.ru
ORCID iD: 0000-0001-5748-178X
SPIN 代码: 1712-9809
Scopus 作者 ID: 7006690997
MD, PhD, Professor
俄罗斯联邦, 3A, Novogireevskaya str., Moscow, 111123参考
- De Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664–670. doi: 10.1002/ijc.30716.
- Брико Н.И., Лопухов П.Д., Каприн А.Д., и др. ВПЧ-ассоциированные поражения в Российской Федерации: оценка состояния проблемы // Современная онкология. ― 2019. ― Т.21. ― №1. ― С. 45–50. [Briko NI, Lopukhov PD, Kaprin AD, et al. HPV-associated lesions in the Russian Federation: assessment of the problem. Sovremennaya onkologiya. 2019;21(1):45–50. (In Russ).] doi: 10.26442/18151434.2019.190199.
- Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2017 году (заболеваемость и смертность). ― М.: МНИОИ им. П.А. Герцена – филиал ФГУ «НМИРЦ» Минздрава России, 2018. ― 250 с. [Kaprin AD, Starinskii VV, Petrova GV. Zlokachestvennye novoobrazovaniya v Rossii v 2017 godu (zabolevaemost’ i smertnost’). Moscow: Moskovskii nauchno-issledovatel’skii onkologicheskii institut imeni P.A. Gertsena − filial FGU «NMIRTS» Minzdrava Rossii; 2018. 250 p. (In Russ).]
- Barchuk A, Bespalov A, Huhtala H, et al. Breast and cervical cancer incidence and mortality trends in Russia 1980–2013. Cancer Epidemiol. 2018;55:73–80. doi: 10.1016/j.canep.2018.05.008.
- Fairley CK, Donovan B. What can surveillance of genital warts tell us? Sex Health. 2010;7(3):325–327. doi: 10.1071/SH09145.
- Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis. 2013;13:39. doi: 10.1186/1471-2334-13-39.
- Bruni L, Albero G, Serrano B, et al. Human papillomavirus and related diseases report. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre); 2019 [cited 2019 June 17]. Available from: https://hpvcentre.net/statistics/reports/XWX.pdf.
- Simms KT, Steinberg J, Caruana M, et al. Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries, 2020–99: a modelling study. Lancet Oncol. 2019;20(3):394–407. doi: 10.1016/S1470-2045(18)30836-2.
- Hall MT, Simms KT, Lew JB, et al. The projected timeframe until cervical cancer elimination in Australia: a modelling study. Lancet Public Health. 2019;4(1):19–27. doi: 10.1016/S2468-2667(18)30183-X.
- Зароченцева Н.В., Белая Ю.М. Опыт реализации программ первичной профилактики заболеваний, вызываемых вирусом папилломы человека, в Московской области // Эпидемиология и вакцинопрофилактика. ― 2017. ― Т.16. ― №6. ― С. 59–65. [Zarochentseva NV, Belaiya JM. Experience in the implementation of programs for primary prevention of human papillomavirus-associated diseases in the Moscow region). Epidemiologiia i vaktsinoprofilaktika. 2017;16(6):59–65. (In Russ).] doi: 10.31631/2073-3046-2017-16-6-59-65.
- Каприн А.Д., Новикова Е.Г., Трушина О.И., Грецова О.П. Cкрининг рака шейки матки ― нерешенные проблемы // Исследования и практика в медицине. ― 2015. ― Т.2. ― №1. ― С. 36–41. [Kaprin AD, Novikova EG, Trushina OI, Gretzova OP. The cervical cancer screening ― unsolved problems. Issledovaniia i praktika v meditsine. 2015;2(1):36–41. (In Russ).] doi: 10.17709/2409-2231-2015-2-1-36-41.
- Winer RL, Hughes JP, Feng Q, et al. Condom use and the risk of genital human papillomavirus infection in young women. N Engl J Med. 2006;354(25):2645–2654. doi: 10.1056/NEJMoa053284.
补充文件
