Features of the clinical course of rheumatoid arthritis in women during pregnancy

The study involved 52 women with rheumatoid arthritis, aged 18 to 29, including 19 pregnant women. The comparison of the clinical features of the process activity with the content of cortisol in the blood, anti-lymphocytic antibodies and rheumatoid factor was carried out. In women with rheumatoid arthritis, a decrease in the content of cortisol with a tendency to an increase in the titer of anti-lymphocyte antibodies and a significant increase in these indicators during pregnancy was found. Low cortisol levels were observed in the exacerbation phase of the rheumatoid process. The data obtained indicate the effect of the concentration of cortisol in the blood and the titer of anti-lymphocyte antibodies on the pathogenesis of rheumatoid arthritis, as well as the need to develop a tactic for treating women with this pathology.