About the role of antibodies formation in the decrease of therapeutic effect of captopril in patients with arterial hypertension

V. P. Tikhonov; Тихонов В. П.; O. V. Ilyukhin; Илюхин О. В.; A. T. Yakovlev; Яковлев А. Т.; M. E. Statsenko; Стаценко М. Е.; D. A. Kirakozov; Киракозов Д. А.; A. S. Popova; Попова А. С.

doi:10.17816/kazmj64582

About the role of antibodies formation in the decrease of therapeutic effect of captopril in patients with arterial hypertension

Authors: Tikhonov V.P.¹, Ilyukhin O.V.¹, Yakovlev A.T.¹, Statsenko M.E.¹, Kirakozov D.A.¹, Popova A.S.¹
Affiliations:
1. Volgograd Medical Academy
Issue: Vol 79, No 5 (1998)
Pages: 379-381
Section: Articles
URL: https://bakhtiniada.ru/kazanmedj/article/view/64582
DOI: https://doi.org/10.17816/kazmj64582
ID: 64582

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Abstract

Captopril being hapten is connected with blood serum albumin and is capable to induce antibodies elaboration. Captopril conjugate with bull serum albumin can be used as a specific diagnosticum for the hardphase immunofermental analysis. Specific immunoglobulins are one of the factors of the “escaping” effect development of the captopril hypotensive action.