Clinical and morphological features of Hirschsprung's disease

Abstract

Hirschsprung's disease is usually caused by a congenital absence or underdevelopment of the Auerbach plexus in the wall of a particular section of the colon, resulting in impaired innervation of the tissues of the organ. The smooth muscular tissue is the first and most severely affected; it gradually changes dystrophically without motor pulses so that the zone of intestine devoid of innervation does not peristalsis and does not push intestinal contents through its lumen. The overlying parts of the large intestine are exposed to increased functioning which leads to hypertrophy of the wall and dilatation of the intestinal lumen.

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