The gender-geneticassessment of frequencyoccurrence of diastolicdysfunction and types of hypertonicremodeling in patientswith controlledand uncontrolledarterial hypertension

In this investigation there was revealed the interconnection of the hypertonic remodeling
type and the difficulty of breaking diastolic function from genotypes characterizing the flow of
arterial hypertension. 76 persons have been investigated: 42 persons with controlled arterial
hypertension, 34 persons with uncontrolled arterial hypertension. All patients were compared
by age and sex. The investigation of echocardiography by using the apparatus Medison Sonoace
8000 was conducted. The molecular genetic investigation with determining genotypes of
polymorphic genes ACE, AGT2R1, eNos was also conducted for all patients. So, the connection
of diastolic dysfunction of the heart at women with uncontrolled arterial hypertension is
associated with concentric hypertrophy of the left ventricle. The difficulty of the diastolic
function and the prognosticly unfavourable type of remodeling heart are associated with
genotypes: ACE - II, AGT2R1 - AG, eNos - ab.

AGT2R1, eNos, arterial hypertension, controlled and uncontrolled hypertension, genes of renin-angiotensin system, genotypes of polymorphic genes ACE, AGT2R1, eNos