Effect of insulin resistance on lipid metabolism and myocardial remodelling in patients with arterial hypertension

The study included 55 patients with arterial hypertension and normal fasting glucose levels without diabetes mellitus and manifesting CVD (cardiovascular disease). We investigated clinical history, laboratory tests, calculated index of insulin resistance (HOMA-IR). Our study shows that in the 4-th quartile HOMA-IR was the highest, concentration of triglycerides and left ventricular mass index were also elevated, myocardial remodelling was present. Thus, even in patients with arterial hypertension and normal fasting glucose levels we detected insulin resistance associated with elevated risk of development of atherosclerosis and CVD. For prediction and correct treatment of atherosclerosis and CVD it is appropriate to measure concentration of glucose, insulin level and estimate the index of insulin resistance HOMA-IR.

insulin resistance, myocardial remodelling, insulin, blood serum glucose, hypertriglyceridemia