Features of developing SARS-CoV-2 nucleocapsid protein population-based seroprevalence during the first wave of the COVID-19 epidemic in the Russian Federation
- 作者: Popova A.Y.1, Andreeva E.E.2, Babura E.A.3, Balakhonov S.V.4, Bashketova N.S.5, Bulanov M.V.6, Valeullina N.N.7, Goryaev D.V.8, Detkovskaya N.N.9, Ezhlova E.B.1, Zaitseva N.N.10, Istorik O.A.11, Kovalchuk I.V.12, Kozlovskikh D.N.13, Kombarova S.V.14, Kurganova O.P.15, Kutyrev V.V.16, Lomovtsev A.E.17, Lukicheva L.A.18, Lyalina L.V.19, Melnikova A.A.1, Mikailova O.M.20, Noskov A.K.21, Noskova L.N.22, Oglezneva E.E.23, Osmolovskay T.P.24, Patyashina M.A.25, Penkovskaya N.A.26, Samoilova L.V.27, Smirnov V.S.19, Stepanova T.F.28, Trotsenko O.E.29, Totolyan A.A.19
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隶属关系:
- Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing
- Rospotrebnadzor Office for Moscow
- Rospotrebnadzor Office for Kaliningrad Region
- Irkutsk Research Anti-Plague Institute
- Rospotrebnadzor Office for St. Petersburg
- Center for Hygiene and Epidemiology in the Vladimir Region
- Rospotrebnadzor Office for Chelyabinsk Region
- Rospotrebnadzor Office for Krasnoyarsk Krai
- Rospotrebnadzor Office Primorsky Krai
- Research Institute named after I.N. Blokhina
- Rospotrebnadzor Office for Leningrad Region
- Rospotrebnadzor Office for Stavropol Krai
- Rospotrebnadzor Office for Sverdlovsk Region
- Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky
- Rospotrebnadzor Office for Amur Region
- Russian Research Anti-Plague Institute “Microbe”
- Rospotrebnadzor Office for Tula Region
- Rospotrebnadzor Office for Murmansk Region
- St. Petersburg Pasteur Institute
- Rospotrebnadzor Office for Moscow Region
- Rostov-on-Don Anti-Plague Institute
- Rospotrebnadzor Office for Astrakhan Region
- Rospotrebnadzor Office for Belgorod Region
- Rospotrebnadzor Office for Krasnodar Krai
- Rospotrebnadzor Office for the Republic of Tatarstan
- Rospotrebnadzor Office for the Republic of Crimea
- Rospotrebnadzor Office for Novosibirsk Region
- Tyumen Research Institute of Regional Infectious Pathology
- Khabarovsk Research Institute of Epidemiology and Microbiology
- 期: 卷 11, 编号 2 (2021)
- 页面: 297-323
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/2220-7619/article/view/118929
- DOI: https://doi.org/10.15789/2220-7619-FOD-1684
- ID: 118929
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全文:
详细
The novel coronavirus (SARS-CoV-2) pandemic, dubbed COVID-19, has become one of the most serious challenges for human populations in the vast majority of countries worldwide. Rapid spreading and increased mortality related to it required new approaches to manage epidemic processes on a global scale. One of such approaches was based on analyzing SARS-CoV-2 seroprevalence associated with COVID-19. Our aim was to summarize the results on assessing seroprevalence to the SARS-CoV-2 nucleocapsid antigen (Nc) in residents from 26 regions of the Russian Federation, carried out during the first wave of the COVID-19 epidemic.
Materials and methods. Seroprevalence distribution was examined in 26 model regions of the Russian Federation according to the unified method developed by the Rospotrebnadzor with the participation of the Federal State Institution Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology. Such approach implied formation of a group of volunteer subjects in model geographic region who were tested by ELISA for anti-Nc serum antibody level in peripheral blood. Analyzed primary data obtained in separate regions were either accepted for publication or released.
Results. The current paper finalizes the data obtained in all 26 regions of the Russian Federation. The total SARS-CoV-2 seroprevalence was 19.5 (10.0–25.6)% with the maximum and minimum value found in the Kaliningrad Region and the Republic of Crimea, respectively (50.2% vs. 4.3%). A pattern of age-related seroprevalence distribution indicates insignificant predominance of seroprevalence among subjects of 1–17 years old: 22.1 (13.1–31.8)%. Among COVID-19 convalescents positive for SARS-CoV Nc antibodies it reached 60.0 (40.0–73.3)%. The number of contact persons comprised 6285 subjects or 8.5% of total volunteer cohort, with the level of seroprevalence reaching up to 25.3 (17.95–35.8)%. A direct correlation was revealed between levels of seroprevalence in convalescent and contact volunteers. In addition, the reproductive number for SARS-CoV was calculated comprising 5.8 (4.3–8.5) suggesting that one convalescent subject can infect at least 4 healthy individuals. A high level of asymptomatic forms of COVID-19 among seropositive subjects was confirmed empirically comprising up to 93.6 (87.1–94.9)%.
Conclusion. A single cross-sectional study performed during 2020 June–August timeframe allowed to assess pattern of sex- and agerelated COVID-19 seroprevalence for general population in 26 Russian Federation regions. The data obtained may serve as a basis for the longitudinal cohort investigation with serial subject sampling. The timing and duration of study will be determined by dynamics of ongoing COVID-19 epidemic.
作者简介
A. Popova
Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-2567-9032
PhD, MD (Medicine), Professor, Head of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor).
Moscow.
俄罗斯联邦E. Andreeva
Rospotrebnadzor Office for Moscow
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Moscow.
Moscow.
俄罗斯联邦E. Babura
Rospotrebnadzor Office for Kaliningrad Region
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0002-4610-752X
Head of Rospotrebnadzor Office for Kaliningrad Region.
Kaliningrad.
俄罗斯联邦S. Balakhonov
Irkutsk Research Anti-Plague Institute
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-4201-5828
PhD, MD (Medicine), Professor, Director.
Irkutsk.
俄罗斯联邦N. Bashketova
Rospotrebnadzor Office for St. Petersburg
Email: vssmi@mail.ru
Head of Rospotrebnadzor Office for St. Petersburg.
St. Petersburg.
俄罗斯联邦M. Bulanov
Center for Hygiene and Epidemiology in the Vladimir Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Vladimir Region.
Vladimir.
俄罗斯联邦N. Valeullina
Rospotrebnadzor Office for Chelyabinsk Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Chelyabinsk Region.
Chelyabinsk.
俄罗斯联邦D. Goryaev
Rospotrebnadzor Office for Krasnoyarsk Krai
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Krasnoyarsk Krai.
Krasnoyarsk.
俄罗斯联邦N. Detkovskaya
Rospotrebnadzor Office Primorsky Krai
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Primorsky Krai.
Vladivostok.
俄罗斯联邦E. Ezhlova
Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing
Email: 123123@pasteurorg.ru
PhD (Medicine), Deputy Head of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing.
Moscow.
俄罗斯联邦N. Zaitseva
Research Institute named after I.N. Blokhina
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0001-5370-4026
PhD, MD (Medicine), Alternate of Deputy Director for Academic Affairs.
Nyzhniy Novgorod.
俄罗斯联邦O. Istorik
Rospotrebnadzor Office for Leningrad Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Leningrad Region.
St. Petersburg.
俄罗斯联邦I. Kovalchuk
Rospotrebnadzor Office for Stavropol Krai
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Stavropol Krai.
Stavropol.
俄罗斯联邦D. Kozlovskikh
Rospotrebnadzor Office for Sverdlovsk Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Sverdlovsk Region.
Ekaterinburg.
俄罗斯联邦S. Kombarova
Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-3382-6178
PhD, MD (Biology), Director.
Moscow.
俄罗斯联邦O. Kurganova
Rospotrebnadzor Office for Amur Region
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-3010-3054
Head of Rospotrebnadzor Office for Amur Region.
Blagoveshchensk.
俄罗斯联邦V. Kutyrev
Russian Research Anti-Plague Institute “Microbe”
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-3788-3452
RAS Full Member, PhD, MD (Medicine), Professor, Director.
Saratov.
俄罗斯联邦A. Lomovtsev
Rospotrebnadzor Office for Tula Region
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0002-4827-9587
Head of Rospotrebnadzor Office for Tula Region.
Tula.
俄罗斯联邦L. Lukicheva
Rospotrebnadzor Office for Murmansk Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Murmansk Region.
Murmansk.
俄罗斯联邦L. Lyalina
St. Petersburg Pasteur Institute
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0001-9921-3505
PhD, MD (Medicine), Professor, Head of the Laboratory of Epidemiology of Infectious and Non-Infectious Diseases.
St. Petersburg.
俄罗斯联邦A. Melnikova
Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0002-5651-1331
PhD (Medicine), Deputy Head of the Epidemiological Surveillance Department.
Moscow.
俄罗斯联邦O. Mikailova
Rospotrebnadzor Office for Moscow Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Moscow Region.
Mytishchi.
俄罗斯联邦A. Noskov
Rostov-on-Don Anti-Plague Institute
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-0550-2221
PhD (Medicine), Director.
Rostov-on-Don.
俄罗斯联邦L. Noskova
Rospotrebnadzor Office for Astrakhan Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Astrakhan Region.
Astrakhan.
俄罗斯联邦E. Oglezneva
Rospotrebnadzor Office for Belgorod Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Belgorod Region.
Belgorod.
俄罗斯联邦T. Osmolovskay
Rospotrebnadzor Office for Krasnodar Krai
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-0471-9015
Head of Rospotrebnadzor Office for Krasnodar Krai.
Krasnodar.
俄罗斯联邦M. Patyashina
Rospotrebnadzor Office for the Republic of Tatarstan
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0002-6302-3993
PhD, MD (Medicine), Associate Professor, Head of Rospotrebnadzor Office for the Republic of Tatarstan.
Kazan.
俄罗斯联邦N. Penkovskaya
Rospotrebnadzor Office for the Republic of Crimea
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for the Republic of Crimea.
Simferopol.
俄罗斯联邦L. Samoilova
Rospotrebnadzor Office for Novosibirsk Region
Email: 123123@pasteurorg.ru
Head of Rospotrebnadzor Office for Novosibirsk Region.
Novosibirsk.
俄罗斯联邦V. Smirnov
St. Petersburg Pasteur Institute
编辑信件的主要联系方式.
Email: vssmi@mail.ru
ORCID iD: 0000-0002-2723-1496
Vyacheslav S. Smirnov - PhD, MD (Medicine), Professor, Leading Researcher, Laboratory of Molecular Immunology.
197101, St. Petersburg, Mira str., 14.
Phone: +7 (911) 948-59-22 (mobile)
俄罗斯联邦T. Stepanova
Tyumen Research Institute of Regional Infectious Pathology
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0002-6289-6274
PhD, MD (Medicine), Professor, Director.
Tyumen.
俄罗斯联邦O. Trotsenko
Khabarovsk Research Institute of Epidemiology and Microbiology
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-3050-4472
PhD, MD (Medicine), Director.
Khabarovsk.
俄罗斯联邦Areg Totolyan
St. Petersburg Pasteur Institute
Email: 123123@pasteurorg.ru
ORCID iD: 0000-0003-4571-8799
RAS Full Member, PhD, MD (Medicine), Professor, Director.
St. Petersburg.
俄罗斯联邦参考
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