Clinical manifestations of decreased ovarian reserve in premenopausal women: a cross-sectional study
- 作者: Salimova M.D.1, Danusevich I.N.1, Nadelyaeva Y.G.1, Lazareva L.M.1, Atalyan A.V.1, Novikova E..1, Sholokhov L.F.1, Rashidova M.A.1, Suturina L.V.1
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隶属关系:
- Scientific Centre for Family Health and Human Reproduction Problems
- 期: 卷 29, 编号 8 (2022)
- 页面: 587-597
- 栏目: ORIGINAL STUDY ARTICLES
- URL: https://bakhtiniada.ru/1728-0869/article/view/106718
- DOI: https://doi.org/10.17816/humeco106718
- ID: 106718
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AIM: To estimate clinical manifestation of decreased ovarian reserve in women of reproductive age from Eastern Siberia.
MATERIAL AND METHODS: A total of 1119 women aged 18 to 40 years who underwent an annual preventive medical examination at their place of work were invited to participate in a cross-sectional study performed in 2017–2019 in Irkutsk Region and Buryat Republic (Russia). Among the 1119 women, 907 aged 31.78±5.13 years were included in the study, after which clinical, instrumental, and laboratory research methods and statistical analysis were utilized. Among the 907 women included in the study, 117 (12.9%) had <5 follicles per ovary and were diagnosed with decreased ovarian reserve (DOR). The laboratory study showed that 56 of the 117 (47.8%) women had an antimullerian hormone (AMH) level below 1.2 ng/mL, the average value of which was 0.53±0.43 ng/mL.
RESULTS: In women with reduced AMH levels, a shortening of the menstrual cycle (p=0.0187) and high parity were observed. Moreover, premature ovarian failure was diagnosed in 4 of the 117 (3.4%) patients with a reduced number of antral follicles.
CONCLUSION: The frequency of women with DOR in the Eastern Siberia region based on one AFC criterion was 12.9%. Only 3.4% of women satisfied all criteria for premature ovarian failure. The average age of women with signs of DOR in this region was 35.12±3.87 years and did not depend on ethnicity. Moreover, 47.8% of the women with an AMH <1.2 had a follicle-stimulating hormone (FSH) level of 12.14 ME/mL, while 52.2% of the those with AMH >1.2 had a FSH level of 5.91 ME/mL. Patients with AMH <1.2 can be characterized by high parity in the anamnesis and shortening of the menstrual cycle.
作者简介
Madinabonu Salimova
Scientific Centre for Family Health and Human Reproduction Problems
编辑信件的主要联系方式.
Email: madinochka.salimova@mail.ru
ORCID iD: 0000-0002-1432-4239
SPIN 代码: 6284-3561
junior research associate
俄罗斯联邦, IrkutskIrina Danusevich
Scientific Centre for Family Health and Human Reproduction Problems
Email: irinaemails@gmail.com
ORCID iD: 0000-0002-8862-5771
SPIN 代码: 6289-3358
Dr. Sci. (Med.)
俄罗斯联邦, IrkutskYana Nadelyaeva
Scientific Centre for Family Health and Human Reproduction Problems
Email: ianadoc@mail.ru
ORCID iD: 0000-0002-5747-7315
SPIN 代码: 7766-5841
Cand. Sci. (Med.), research associate
俄罗斯联邦, IrkutskLyudmila Lazareva
Scientific Centre for Family Health and Human Reproduction Problems
Email: lirken_@mail.ru
ORCID iD: 0000-0002-7662-8529
SPIN 代码: 7056-7495
Cand. Sci. (Med.), research associate
俄罗斯联邦, IrkutskAlina Atalyan
Scientific Centre for Family Health and Human Reproduction Problems
Email: atalyan@sbamsr.irk.ru
ORCID iD: 0000-0002-3407-9365
SPIN 代码: 3975-8304
Cand. Sci. (Biol.), senior research associate
俄罗斯联邦, IrkutskEvgenia Novikova
Scientific Centre for Family Health and Human Reproduction Problems
Email: europe411@mail.ru
ORCID iD: 0000-0002-9353-7928
SPIN 代码: 8473-7941
junior research associate
俄罗斯联邦, IrkutskLeonid Sholokhov
Scientific Centre for Family Health and Human Reproduction Problems
Email: lfshol@mail.ru
ORCID iD: 0000-0003-3588-6545
SPIN 代码: 4138-8991
MD, Cand. Sci. (Med.)
俄罗斯联邦, IrkutskMaria Rashidova
Scientific Centre for Family Health and Human Reproduction Problems
Email: rashidovama@mail.ru
ORCID iD: 0000-0003-4730-5154
SPIN 代码: 1361-0840
Cand. Sci. (Biol.), research associate
俄罗斯联邦, IrkutskLarisa Suturina
Scientific Centre for Family Health and Human Reproduction Problems
Email: lsuturina@mail.ru
ORCID iD: 0000-0002-6271-7803
SPIN 代码: 9419-0244
Dr. Sci. (Med.), professor, chief research associate
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