绝经早期女性复发性外阴阴道念珠菌病的综合疗养治疗效果研究
- 作者: Bestaeva A.Е.1, Ipatova M.V.2, Kaisinova A.S.1,3
-
隶属关系:
- North Caucasian Federal Scientific and Clinical Centre
- Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology
- Pyatigorsk Medical and Pharmaceutical Institute — Volgograd State Medical University
- 期: 卷 24, 编号 2 (2025)
- 页面: 117-124
- 栏目: Original studies
- URL: https://bakhtiniada.ru/1681-3456/article/view/316578
- DOI: https://doi.org/10.17816/rjpbr643061
- EDN: https://elibrary.ru/BVZOHD
- ID: 316578
如何引用文章
详细
论证。 由于年龄及生理特征,绝经早期女性对治疗方案的可变性较为敏感,这可能影响念珠菌属(Candida spp.)的粘附活性,并导致复发性外阴阴道念珠菌病的发生。综合疗养治疗因其良好的生理适应及康复效应,在该病的治疗策略中具有较大前景。
目的。 评估综合疗养治疗对绝经早期女性复发性外阴阴道念珠菌病的疗效。
材料与方法。研究共纳入108例绝经早期女性复发性外阴阴道念珠菌病患者,并采用简单随机抽样法分为三组:对照组(n=36,第3组)接受标准妇科疾病综合疗养治疗;对比组(n=36,第2组)在对照组基础上联合泥疗;实验组(n=36,第1组)在对比组基础上联合内生按摩及磁场疗法。疗效评估指标包括阴道微生态检测、阴道萎缩程度、医学心理测试。
结果。几乎每两名实验组(第1组)患者中就有一名在治疗结束及随访6个月后,其阴道微生态被归类为绝对正常状态,而在12个月后,微生态呈中间型涂片,与健康绝经早期女性相符;在对比组(第2组),治疗后第18天及随访6个月时阴道微生态达到条件性正常,但仍以中间型涂片为主;在对照组(第3组),所有随访阶段均呈现菌群失调状态。随访6个月时,第1组和第2组的阴道萎缩程度均有所改善,但仅在第1组观察到最低程度的萎缩变化。第1组患者的健康状况、活动能力和情绪在疗养治疗结束时显著改善,并达到正常标准。第2组患者的健康状况被评估为良好,并在统计学上显著不同于第1组。需要强调的是,第1组与第3组之间存在显著差异。
结论。针对绝经早期女性复发性外阴阴道念珠菌病的创新综合疗养治疗方案有助于恢复阴道微生态平衡,降低阴道萎缩程度,显著改善生活质量。
关键词
作者简介
Angela Е. Bestaeva
North Caucasian Federal Scientific and Clinical Centre
Email: an.beataeva@yandex.ru
ORCID iD: 0009-0004-0371-3302
SPIN 代码: 1156-7981
俄罗斯联邦, Essentuki
Marina V. Ipatova
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology
Email: mavlip@yandex.ru
ORCID iD: 0000-0003-2094-8571
SPIN 代码: 1006-6969
MD, Dr. Sci. (Medicine)
俄罗斯联邦, MoscowAgnessa S. Kaisinova
North Caucasian Federal Scientific and Clinical Centre; Pyatigorsk Medical and Pharmaceutical Institute — Volgograd State Medical University
编辑信件的主要联系方式.
Email: zamoms@skfmba.ru
ORCID iD: 0000-0003-1199-3303
SPIN 代码: 6552-9684
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, Essentuki; Pyatigorsk参考
- Suhih GT, Prilepskaya VN, Nazarova NM, et al. Diagnosis, treatment and prevention of diseases of the vulva and vagina in obstetrics and gynecology. Moscow: LLC ID Tretyakov; 2024. (In Russ.) EDN: VVPCUS
- Fasola E, Bosoni D. Dynamic quadripolar radiofrequency: pilot study of a new high-tech strategy for prevention and treatment of vulvar atrophy. Aesthet Surg J. 2019;39(5):544–552.
- Serov VN, Silant'eva ES, Ipatova MV, et al. Safety of physiotherapy in gynecological patients. Obstetrics and gynecology. 2007;3:74–77. EDN: IAUMTZ
- Inflammatory diseases of female pelvic organs: Russian clinical guidelines. Russian Society of Obstetricians and Gynecologists. Moscow; 2020. (In Russ.)
- Abuseva GR, Badtieva VA, Didur MD, et al. Physical and rehabilitation medicine normative legal regulation. Methodical recommendations. Saint Petersburg; 2020. (In Russ.) EDN: LNMPVO
- Epifanov VA, Kotenko KV, Korchazhkina NB, et al. Medical rehabilitation in obstetrics and gynecology. Moscow: «GEOTAR-Media»; 2023. (In Russ.) EDN: EOQERU
- Ujba VV, Kotenko KV, Orlova GV. Application of non-drug programs for correction of metabolic syndrome. Physiotherapy, balneology and rehabilitation. 2011;1:40–42. EDN: NDOAKT
- Kotenko KV, Frolkov VK, Nagornev SN, et al. Prospects for the use of drinking mineral waters in the rehabilitation of patients with coronavirus (COVID-19) infection: analysis of the main sanogenetic mechanisms. Issues of balneology, physiotherapy and therapeutic physical training. 2021;98(6–2):75–84. doi: 10.17116/kurort20219806275 EDN: RDBRST
- Razumov AN, Badtieva VA, Knyazeva TA. Non-drug therapy as a method of partial correction of proatherogenic shifts during long-term use of beta-blockers and thiazide diuretics. Issues of balneology, physiotherapy and therapeutic physical training. 2002;6:5–9. (In Russ.) EDN: VSUTUV
- Razumov AN, Ponomarenko GN, Badtieva VA, et al. Medical rehabilitation of patients who have had COVID-19 in health resort organizations. Methodological recommendations. Saint Petersburg; 2021. (In Russ.) EDN: AEDCML
- Ujba VV, Kotenko KV, Kolbahova SN. The latest technologies in restorative medicine for the treatment of occupational lung diseases. In: Proceedings of the First All-Russian Congress of Physicians of Restorative Medicine, Moscow, February 27 — March 1, 2007. Moscow: LLC «MEDI Expo»; 2007. 282 p. (In Russ.) EDN: QBOLBV
- Cyganova TN, Frolkov VK, Korchazhkina NB. Pathogenetic rationale for the use of hypo-hyperoxic training in the treatment and prevention of complications of coronavirus infection COVID-19. Physiotherapist. 2021;1:14–25. doi: 10.33920/med-14-2102-02 EDN: FBVVIW
- Efendieva MT, Badtieva VA, Rusenko NI. Magnesium-containing mineral waters in the treatment of patients with cardiac manifestations of gastroesophageal reflux disease. Issues of balneology, physiotherapy and therapeutic physical training. 2006;6:31–34. EDN: HDSZYC
- Kotenko KV, Ujba VV, Korchazhkina NB, et al. Instructions for conducting additional methods of examination and rehabilitation of athletes. Moscow; 2012. 25 p. (In Russ.) EDN: QBXBWL
- Kotenko KV, Ujba VV, Korchazhkina NB, et al. Improving the functional capabilities of athletes in cyclic sports. Occupational medicine and industrial ecology. 2013;9:42–44. EDN: RCDVZB
- SHarykin AS, Badtieva VA, Pavlov VI. Sports cardiology: a guide for cardiologists, pediatricians, physicians of functional diagnostics and sports medicine, trainers. Moscow: Izdatel'stvo «Ikar»; 2017. (In Russ.)
- Korchazhkina NB, Ashihmina MV, Gurvich VB, et al. The use of unloading-dietary therapy in restorative medicine. Moscow; 2004. (In Russ.) EDN: QBVDLR
- Korchazhkina NB, Mihajlova AA. Features of the use of stabiloplatforms with biofeedback in various socially significant diseases. Physiotherapy, balneology and rehabilitation. 2019; 18(2):103–106. doi: 10.17816/1681-3456-2019-18-2-103-106 EDN: KXDZOQ
- Mihajlova AA, Korchazhkina NB, Koneva ES, Kotenko KV. Psychocorrective effect of using combined methods of medical rehabilitation in patients who have suffered an ischemic stroke. Physiotherapy, balneology and rehabilitation. 2020;19(6): 380–383. doi: 10.17816/1681-3456-2020-19-6-5 EDN: UBARKW
- Kotenko KV, Korchazhkina NB, Kuzovlev OP, et al. Rehabilitation program for patients with dorsopathies: A training manual for doctors. Moscow; 2005. (In Russ.) EDN: QBUUKH



