Study of HIF-1α, HIF-2α and VEGF-A dynamics in plasma as potential markers of endothelial dysfunction and acute respiratory distress syndrome in patients with severe COVID-19 pneumonia
- Autores: Raitsev S.N.1, Zvyagina V.I.1, Maksaev D.A.1, Chobanian A.A.1, Raitseva O.V.1
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Afiliações:
- Ryazan State Medical University
- Edição: Volume 28, Nº 12 (2025)
- Páginas: 77-83
- Seção: Medical chemistry
- URL: https://bakhtiniada.ru/1560-9596/article/view/362638
- DOI: https://doi.org/10.29296/25877313-2025-12-09
- ID: 362638
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Resumo
Introduction. Impaired adaptation to hypoxia in COVID-19 pneumonia may lead to endothelial dysfunction and acute respiratory distress syndrome (ARDS). In this regard, the prognostic value of determining plasma levels of HIF-1α, HIF-2α, and VEGF-A has been actively studied, but their significance in relation to the development of ARDS is poorly understood.
Aim of the study – to evaluate the dynamics of HIF-1α, HIF-2α and VEGF-A in plasma of patients with COVID-19 pneumonia as potential markers of endothelial dysfunction and ARDS development.
Material and Methods. HIF-1α, HIF-2α and VEGF-A levels were studied in plasma at the time of admission and on the 7th day of treatment in 90 patients (47 women, 43 men) aged 31 to 86 years (median 65 years) with different severity of COVID-19 pneumonia (moderately severe course – 35, severe course – 28, extremely severe course – 27). The amount of HIF-1α, HIF-2α and VEGF-A was determined in blood plasma using ELISA kits.
Results. Patients with extremely severe disease had significantly lower plasma HIF-1α levels on admission than patients with moderate severity, while VEGF-A levels were significantly higher. These differences were also reflected in clinical outcomes, as HIF-1α level on admission was positively correlated with the risk of developing ARDS (r=0.483, p<0.01), while VEGF-A level was negatively correlated with ROX index (r=–0.339, p<0.05) and associated with a lower risk of developing ARDS (r=-0.378, p<0.05).
Conclusions. Patients with severe COVID-19 pneumonia have elevated levels of VEGF-A upon admission, indicating the development of endothelial dysfunction. Plasma HIF-1α and VEGF-A levels on admission, but not on day 7, are associated with the risk of ARDS in COVID-19 patients. Lower HIF-1α and higher VEGF-A at admission indicate increased risk. Evaluation of baseline and dynamics of markers of adaptation to hypoxia and development of endothelial dysfunction is important for predicting COVID-19 outcomes.
Sobre autores
S. Raitsev
Ryazan State Medical University
Autor responsável pela correspondência
Email: raitsevsergei@yandex.ru
ORCID ID: 0000-0002-6892-1768
Código SPIN: 3922-6472
Post-graduate Student, Department of Biological Chemistry
Rússia, 9 Vysokovoltnaya str., Ryazan, 390026V. Zvyagina
Ryazan State Medical University
Email: raitsevsergei@yandex.ru
ORCID ID: 0000-0003-2800-5789
Código SPIN: 7553-8641
Dr.Sc. (Med.), Associate Professor, Department of Biological Chemistry
Rússia, 9 Vysokovoltnaya str., Ryazan, 390026D. Maksaev
Ryazan State Medical University
Email: raitsevsergei@yandex.ru
ORCID ID: 0000-0003-3299-8832
Código SPIN: 9962-2923
Ph.D. (Med.), Associate Professor, Department of Cardiovascular, X-ray Endovascular Surgery and Radiation Diagnostics
Rússia, 9 Vysokovoltnaya str., Ryazan, 390026A. Chobanian
Ryazan State Medical University
Email: raitsevsergei@yandex.ru
ORCID ID: 0000-0002-8129-5976
Código SPIN: 4639-9650
Ph.D. (Med.), Assistant, Department of Cardiovascular, X-ray Endovascular Surgery and Radiation Diagnostics
Rússia, 9 Vysokovoltnaya str., Ryazan, 390026O. Raitseva
Ryazan State Medical University
Email: raitsevsergei@yandex.ru
ORCID ID: 0009-0001-0664-6211
Student, Faculty of Pediatrics
Rússia, 9 Vysokovoltnaya str., Ryazan, 390026Bibliografia
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