Enviar artigo por via de e-mail Synthesis of Macrocyclic Ttipeptidopyridine Schiff Base Candidates
- Autores: Sallam H.A.1, Abdel-Mageid R.E.2, Amr A.E.3,4
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Afiliações:
- Synthetic Organic Lab, Chemistry Department, Faculty of Science
- Department of Photochemistry
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC)
- Applied Organic Chemistry Department
- Edição: Volume 89, Nº 11 (2019)
- Páginas: 2308-2313
- Seção: Article
- URL: https://bakhtiniada.ru/1070-3632/article/view/223177
- DOI: https://doi.org/10.1134/S1070363219110239
- ID: 223177
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Resumo
In the current study, a series of macrocyclic tripeptide Schiff bases 2–6 were synthesized by using macrocyclic tripeptide hydrazide 1 as starting material. Treatment of hydrazide 1 with active carbonyl cycloalkanones gave cycloalkanone hydrazines 2a–2d. Also, condensation of 1 with aromatic and heterocyclic aldehydes, or aromatic and heterocyclic acetyl derivatives afforded the corresponding Schiff base candidates 3a–3e, 4a–4c, 5a–5c, and 6a–6c, respectively.
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Sobre autores
H. Sallam
Synthetic Organic Lab, Chemistry Department, Faculty of Science
Email: aamr@ksu.edu.sa
Egito, Abbassia, Cairo, 11566
R. Abdel-Mageid
Department of Photochemistry
Email: aamr@ksu.edu.sa
Egito, Dokki, Cairo, 12622
A. Amr
Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC); Applied Organic Chemistry Department
Autor responsável pela correspondência
Email: aamr@ksu.edu.sa
Arábia Saudita, Riyadh, 11451; Dokki, Cairo, 12622
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