Interaction of benzene, L-histidine and L-proline with urea, N,N-dimethylpropyleneurea, and N,N-dimethylformamide in water

Resumo

The paper focuses on the interaction of two heterocyclic amino acids and hydrophobic benzene with urea, dimethylformamide, and dimethylpropyleneurea in water at 298 and 313 K. The enthalpy and heat capacity parameters of the solute‒amide pair and triplet interactions have been computed via virial expansion technique. The results are discussed in terms of solvation effects in mixed solvents and their influence on the denaturation of globular proteins.