Мақаланы E-mail арқылы жіберу Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4
- Авторлар: Ragha Suma V.1,2, Sreenivasulu R.3, Subramanyam M.2, Rao K.R.4
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Мекемелер:
- Department of Chemistry, GITAM Institute of Science
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Department of Chemistry, GITAM Institute of Technology
- Шығарылым: Том 89, № 3 (2019)
- Беттер: 499-504
- Бөлім: Article
- URL: https://bakhtiniada.ru/1070-3632/article/view/222800
- DOI: https://doi.org/10.1134/S1070363219030228
- ID: 222800
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Аннотация
A new series of amide derivatives of structurally modified combretastatin-A4 10a–10j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The products are tested for their anticancer activity towards human cancer cell lines, MCF-7 (breast), A-549 (lung), Colo-205 (colon), and A-2780 (ovarian). The compounds 10b, 10c, and 10d demonstrate the most promising activity.
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Авторлар туралы
V. Ragha Suma
Department of Chemistry, GITAM Institute of Science; Department of Chemistry
Email: rammohanrao.k@gmail.com
Үндістан, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045; Bhadrachalam, Telangana, 507111
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rammohanrao.k@gmail.com
Үндістан, Kakinada, Andhra Pradesh, 533003
M. Subramanyam
Department of Chemistry
Email: rammohanrao.k@gmail.com
Үндістан, Khammam, Telangana, 507002
K. Rao
Department of Chemistry, GITAM Institute of Technology
Хат алмасуға жауапты Автор.
Email: rammohanrao.k@gmail.com
Үндістан, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045
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