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Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile

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1. Title Title of document Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile
2. Creator Author's name, affiliation, country R. M. Islamova; St. Petersburg State University; Russian Federation
2. Creator Author's name, affiliation, country V. V. Suslonov; Center for X-Ray Diffraction Studies; Russian Federation
2. Creator Author's name, affiliation, country M. Ya. Demakova; St. Petersburg State University; Russian Federation
3. Subject Discipline(s)
3. Subject Keyword(s) oximes; palladium; 4-aminoquinazolines; cross-coupling reactions; metal complex catalysis
4. Description Abstract

4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.

5. Publisher Organizing agency, location Pleiades Publishing, Ltd.
6. Contributor Sponsor(s)
7. Date (DD-MM-YYYY) 01.04.2019
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://bakhtiniada.ru/1070-3632/article/view/222847
10. Identifier Digital Object Identifier (DOI) 10.1134/S1070363219040054
11. Source Title; vol., no. (year) Russian Journal of General Chemistry; Vol 89, No 4 (2019)
12. Language English=en
13. Relation Supp. Files
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2019 Pleiades Publishing, Ltd.