A Water Soluble Zinc(II) Coordination Polymer Containing Pyridazine-4,5-Dicarboxylic Acid: The Crystal Structure and Binding Properties with DNA

Resumo

New water soluble complex [Zn(HPDDA)₂(H₂O)₂(4,4'-Bipy)₂]_n (I), where H₂PDDA is pyridazine- 4,5-dicarboxylic acid, 4,4'-Bipy = 4,4'-bipyridine), has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction analysis (CIF file CCDC no. 835525 ) and elemental analysis. In I, each Zn²⁺ ion is six-coordinated by two oxygen atoms from the two HPDDA ligands, two nitrogen atoms from two 4,4'-Bipy and two oxygen atoms from two water molecules. The interactions of I with calf thymus DNA were studied by circular dichroism spectroscopy. The results indicated that this water soluble zinc complex show moderate binding with DNA and could be used for candidate for therapy of cancer.