Отправить статью по E-mail Phosphocreatine immobilization of the surface of silica and magnetite nanoparticles for targeted drug delivery
- Авторы: Korolev D.V.1,2, Evreinova N.V.1,3, Zakharova E.V.4, Gareev K.G.4, Naumysheva E.B.1,5, Postnov D.V.5, Postnov V.N.1,5, Galagudza M.M.1,2
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Учреждения:
- Almazov National Medical Research Centre
- First Pavlov State Medical University of St. Petersburg
- St. Petersburg State Technological Institute (Technical University)
- St. Petersburg Electrotechnical University “LETI”
- St. Petersburg State University
- Выпуск: Том 68, № 5 (2019)
- Страницы: 1096-1101
- Раздел: Full Article
- URL: https://bakhtiniada.ru/1066-5285/article/view/243386
- DOI: https://doi.org/10.1007/s11172-019-2525-0
- ID: 243386
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Аннотация
A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreatine than silica nanoparticles. The method was recommended for practical application.
Об авторах
D. Korolev
Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Автор, ответственный за переписку.
Email: Korolev_DV@almazovcentre.ru
Россия, 2 ul. Akkuratova, St. Petersburg, 197341; 6—8 ul. L’va Tolstogo, St. Petersburg, 197022
N. Evreinova
Almazov National Medical Research Centre; St. Petersburg State Technological Institute (Technical University)
Email: Korolev_DV@almazovcentre.ru
Россия, 2 ul. Akkuratova, St. Petersburg, 197341; 26 Moskovsky prosp., St. Petersburg, 190013
E. Zakharova
St. Petersburg Electrotechnical University “LETI”
Email: Korolev_DV@almazovcentre.ru
Россия, 5 ul. Prof. Popova, St. Petersburg, 197376
K. Gareev
St. Petersburg Electrotechnical University “LETI”
Email: Korolev_DV@almazovcentre.ru
Россия, 5 ul. Prof. Popova, St. Petersburg, 197376
E. Naumysheva
Almazov National Medical Research Centre; St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Россия, 2 ul. Akkuratova, St. Petersburg, 197341; 7/9 Universitetskaya nab., St. Petersburg, 199034
D. Postnov
St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Россия, 7/9 Universitetskaya nab., St. Petersburg, 199034
V. Postnov
Almazov National Medical Research Centre; St. Petersburg State University
Email: Korolev_DV@almazovcentre.ru
Россия, 2 ul. Akkuratova, St. Petersburg, 197341; 7/9 Universitetskaya nab., St. Petersburg, 199034
M. Galagudza
Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Email: Korolev_DV@almazovcentre.ru
Россия, 2 ul. Akkuratova, St. Petersburg, 197341; 6—8 ul. L’va Tolstogo, St. Petersburg, 197022
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