Reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides with hydroxylamine and biological activity of the products

Аннотация

The reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides (hetaryl is 2-pyridyl, 2-azolyls, benzo[d]thiazol-2-yl) with hydroxylamine yielded 4-aryl-N-hetaryl-2-hydroxyimino-4-oxobutanamides and 5-aryl-N-hetarylisoxazole-3-carboxamides. The products were searched for representatives with high antimicrobial and anti-inflammatory activities and low acute toxicity. A structure—pharmacological activity relationship of the prepared compounds was established.