Enviar artigo por via de e-mail Chitosan modified with terephthaloyl diazide as a drug delivery system
- Autores: Odinokov A.V.1, Dzhons D.Y.1, Budruev A.V.1, Mochalova A.E.1, Smirnova L.A.1
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Afiliações:
- N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
- Edição: Volume 65, Nº 4 (2016)
- Páginas: 1122-1130
- Seção: Full Articles
- URL: https://bakhtiniada.ru/1066-5285/article/view/237967
- DOI: https://doi.org/10.1007/s11172-016-1423-y
- ID: 237967
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Resumo
pH- and thermo-sensitive hydrogels based on chitosan cross-linked with terephthaloyl diazide were synthesized. A new formulation of the polysaccharide modified with taxifolin (dihydroquercetin) was obtained by nucleophylic addition reaction resulting in the formation of urea and urethane bonds with a 1,4-phenylenediamine spacer. Sustained release of the effective agent (flavonoid) upon action of trypsin, which is one of the enzymes of the gastrointestinal tract, was observed.
Sobre autores
A. Odinokov
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Rússia, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
D. Dzhons
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Rússia, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
A. Budruev
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Autor responsável pela correspondência
Email: budruev@gmail.com
Rússia, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
A. Mochalova
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Rússia, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
L. Smirnova
N. I. Lobachevsky State University of Nizhny Novgorod, Chemical Department
Email: budruev@gmail.com
Rússia, 23/5 prosp.Gagarina, Nizhny Novgorod, 603950
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