The Probe Length Effect on the Cantilever of an Atomic Force Microscope in Measuring the Mechanical Properties of Living Neurons


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Аннотация

Living sensory neurons were studied by atomic force microscopy in the PeakForce QNM mode under near-physiological conditions. The dependence of the measured apparent Young modulus of cells on the ratio of the probe height to the beam length on a used cantilever was revealed. A qualitative explanation based on the analysis of beam strains in two limit cases, in which the probe slides over a studied object and the probe sticks to the latter, was given to the obtained result. It was proposed to classify native cells by the character of their interaction with the probe (sliding or sticking).

Авторлар туралы

A. Ankudinov

Ioffe Physical Technical Institute; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics

Хат алмасуға жауапты Автор.
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, Politekhnicheskaya ul. 26, St. Petersburg, 194021; St. Petersburg, 197101

M. Khalisov

St. Petersburg National Research University of Information Technologies, Mechanics, and Optics; Pavlov Institute of Physiology

Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 197101; St. Petersburg, 199034

V. Penniyaynen

Pavlov Institute of Physiology

Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 199034

S. Podzorova

Pavlov Institute of Physiology

Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 199034

K. Timoshchuk

St. Petersburg National Research University of Information Technologies, Mechanics, and Optics; Pavlov Institute of Physiology

Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 197101; St. Petersburg, 199034

B. Krylov

Pavlov Institute of Physiology

Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 199034

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