The Probe Length Effect on the Cantilever of an Atomic Force Microscope in Measuring the Mechanical Properties of Living Neurons
- Авторлар: Ankudinov A.V.1,2, Khalisov M.M.2,3, Penniyaynen V.A.3, Podzorova S.A.3, Timoshchuk K.I.2,3, Krylov B.V.3
-
Мекемелер:
- Ioffe Physical Technical Institute
- St. Petersburg National Research University of Information Technologies, Mechanics, and Optics
- Pavlov Institute of Physiology
- Шығарылым: Том 44, № 8 (2018)
- Беттер: 671-674
- Бөлім: Article
- URL: https://bakhtiniada.ru/1063-7850/article/view/207817
- DOI: https://doi.org/10.1134/S1063785018080035
- ID: 207817
Дәйексөз келтіру
Аннотация
Living sensory neurons were studied by atomic force microscopy in the PeakForce QNM mode under near-physiological conditions. The dependence of the measured apparent Young modulus of cells on the ratio of the probe height to the beam length on a used cantilever was revealed. A qualitative explanation based on the analysis of beam strains in two limit cases, in which the probe slides over a studied object and the probe sticks to the latter, was given to the obtained result. It was proposed to classify native cells by the character of their interaction with the probe (sliding or sticking).
Авторлар туралы
A. Ankudinov
Ioffe Physical Technical Institute; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics
Хат алмасуға жауапты Автор.
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, Politekhnicheskaya ul. 26, St. Petersburg, 194021; St. Petersburg, 197101
M. Khalisov
St. Petersburg National Research University of Information Technologies, Mechanics, and Optics; Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 197101; St. Petersburg, 199034
V. Penniyaynen
Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 199034
S. Podzorova
Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 199034
K. Timoshchuk
St. Petersburg National Research University of Information Technologies, Mechanics, and Optics; Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 197101; St. Petersburg, 199034
B. Krylov
Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Ресей, St. Petersburg, 199034
Қосымша файлдар
