Growth factor dysregulation and placental dysfunction
- 作者: Azizova Z.S.1, Eshimbetova G.Z.2, Zhuraeva D.M.1
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隶属关系:
- Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
- Center for the Development of Professional Qualifications of Medical Workers
- 期: 卷 27, 编号 4 (2024)
- 页面: 845-852
- 栏目: SHORT COMMUNICATIONS
- URL: https://bakhtiniada.ru/1028-7221/article/view/267860
- DOI: https://doi.org/10.46235/1028-7221-16649-GFD
- ID: 267860
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详细
The article is devoted to the study of angiogenic and antiangiogenic vascular growth factors in placental dysfunction, which is of great importance in obstetrics and perinatology. The study of growth factors as predictors of the development of placental dysfunction makes it possible to determine in advance the development of many obstetric pathologies, including preeclampsia and fetal growth retardation, which is of great practical importance. The authors conducted an immunological study of pregnant women with placental dysfunction and pregnant women with a physiological pregnancy. Purpose of the study: to study serum growth factors in women with placental dysfunction.
We examined 47 pregnant women with a gestation period of 26-40 weeks, with a diagnosis of placental dysfunction, who were under observation in the obstetric department of the city maternity complex No. 3 of the city of Tashkent. The control group consisted of 35 women with a physiological pregnancy. All women underwent an immunological blood test: cellular and humoral immunity, as well as cytokines (VEGF-A, PlGF, sFlt-1, sFlt-1/PlGF) were studied. Based on the results obtained, the authors suggest that an increased level of soluble sFlt-1 and a simultaneous decrease in the levels of VEGF-A and PlGF in pregnant women at 26-40 weeks of gestation may portend the development of pregnancy complications, including preeclampsia and fetal growth restriction, and increase the risk of premature birth. Ddelivery due to impaired placental blood flow and oxygen deficiency for the fetus, lead to deterioration of microcirculation, and insufficient levels of VEGF-A and PlGF can contribute to vascular endothelial dysfunction, which can also contribute to the development of preeclampsia. The studied angiogenic and antiangiogenic vascular growth factors are important indicators and can serve as markers for predicting pregnancy complications for active medical intervention in maintaining the health of both mother and child.
作者简介
Z. Azizova
Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
编辑信件的主要联系方式.
Email: zuhra_0203@list.ru
PhD (Biology), Senior Research Associate
乌兹别克斯坦, TashkentG. Eshimbetova
Center for the Development of Professional Qualifications of Medical Workers
Email: zuhra_0203@list.ru
PhD, MD (Medicine), Professor
乌兹别克斯坦, TashkentD. Zhuraeva
Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
Email: zuhra_0203@list.ru
Independent Applicant
乌兹别克斯坦, Tashkent参考
- Макаров О.В., Волкова Е.В., Лысюк Е.Ю., Копылова Ю.В. Фетоплацентарный ангиогенез у беременных с плацентарной недостаточностью // Акушерство, гинекология, репродукция, 2013.Т. 7, № 3. С. 13-19. [Makarov O.V., Volkova E.V., Lysyuk E.Yu., Kopylova Yu.V. Fetoplacental angiogenesis in pregnant women with placental insufficiency. Akusherstvo, ginekologiya, reproduktsiya = Obstetrics, Gynecology, and Reproduction, 2013, Vol. 7, no. 3, pp. 13-19. (In Russ.)]
- Савельева Г.М., Курцер М.А., Шалина Р.И. Материнская смертность и пути ее снижения // Акушерство и гинекология, 2009. Т. 3. С. 11-15. [Savelieva G.M., Kurzer M.A., Shalina R.I. Maternal mortality and ways to reduce it. Akusherstvo i ginekologiya = Obstetrics and Gynecology, 2009, Vol. 3, pp. 11-15. (In Russ.)]
- Сидельникова В.М. Эндокринология беременности в норме и при патологии. М., 2009. 352 с. [Sidel’nikova V.M. Endocrinology of pregnancy in norm and pathology]. Moscow, 2009. 352 p.
- Сидорова И.С., Милованов А.П., Боровкова Е.И., Солоницын А.Н. Иммуногистохимическая оценка распределения фактора роста эндотелия сосудов в плаценте, плацентарном ложе матки при нормальной беременности и у женщин с преэклампсией // Архив патологии, 2008. Т. 1. С. 12-15. [Sidorova I.S., Milovanov A.P., Borovkova E.I., Solonitsyn A.N. Immunohistochemical assessment of vascular endothelial growth factor distribution in the placenta, uterine placental bed in normal pregnancy and in women with preeclampsia. Arkhiv patologii = Archives of Pathology, 2008, Vol. 1, pp. 12-15. (In Russ.)]
- Соколов Д.И. Васкулогенез и ангиогенез в развитии плаценты // Журнал акушерства и женских болезней, 2007. Т. 3. С. 129-133. [Sokolov D.I. Vasculogenesis and angiogenesis in placental development. Zhurnal akusherstva i zhenskikh bolezney = Journal of Obstetrics and Women’s Diseases, 2007, Vol. 3, pp. 129-133. (In Russ.)]
- Стрижаков А.Н., Тимохина Т.Ф., Баев О.Р., Рыбин М.В. Выбор оптимального метода родоразрешения в снижении перинатальных потерь // Акушерство и гинекология, 2000. Т. 5. С. 8-12. [Strizhakov A.N., Timokhina T.F., Baev O.R., Rybin M.V. Choice of optimal method of obstetric resolution in reducing perinatal losses. Akusherstvo i ginekologiya = Obstetrics and Gynecology, 2000, Vol. 5, pp. 8-12. (In Russ.)]
- Burton G.I., Charnock-Jones D.S., Jauniaux E. Regulation of vascular growth and function in the human placenta. Reproduction, 2009, Vol. 138, no. 6, pp. 895-902.
- Del Rio M., Martinez J.M., Bennasar M., Palacio M., Figueras F., Puerto B. Prenatal diagnosis of a right ventricular diverticulum complicated by pericardial effusion in the first trimester. Ultrasound. Obstet. Gynecol., 2005, Vol. 25, pp. 409-411.
- Dias S., Shmelkov S.V., Lam G., Rafii S. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood, 2002, Vol. 99, no. 7, pp. 2532-254.
- Forbes K., Westwood M. Maternal growth factor regulation of placental development and fetal growth. J. Endocrinol., 2010, Vol. 207, pp. 1-16.
- Maynard S.E., Min J.Y., Merchan J. Excess placental soluble fms-like tyrosine kinase 1 (sFltl) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest., 2003, Vol. 111, pp. 649-658.
- Plaisier M., Dennert I., Rost E. Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Hum. Reprod., 2009, Vol. 24, no. 1, pp. 185-197.
- Sugimoto H., Hamano Y., Charytan D., Cosgrove D., Kieran M., Sudhakar A., Kalluri R. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt- 1) induces proteinuria. J. Biol. Chem., 2003, Vol. 278, no. 15, pp. 12605-12608.
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