EFFECTS OF CARBOPLATIN WITH CUCURBIT[7]URIL ON SUBPOPULATION COMPOSITION AND PROLIFERATIVE ACTIVITY OF LYMPHOCYTES IN VITRO
- 作者: Pashkina E.A.1,2, Aktanova A.A.2, Ermakov A.A.2, Knauer N.Y.1, Mirzaeva I.V.3, Kovalenko E.A.3
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隶属关系:
- FSBSI “Research Institute of Fundamental and Clinical Immunology”
- Novosibirsk State Medical University
- Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 462-464
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120261
- DOI: https://doi.org/10.31857/S102872210006930-8
- ID: 120261
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详细
It is known that the use of delivery systems can reduce the toxicity of platinum compounds without losing a high therapeutic effect. In this work, the immunotoxic effect of carboplatin when co-added with cucurbit[7]uril was investigated, including the effect on the subpopulation composition of lymphocytes and their proliferative activity in vitro.
作者简介
E. Pashkina
FSBSI “Research Institute of Fundamental and Clinical Immunology”;Novosibirsk State Medical University
编辑信件的主要联系方式.
Email: pashkina.e.a@yandex.ru
PhD, Researcher, Clinical Immunopathology Laboratory;
Assistant of the Department of Clinical Immunology at the Medical Faculty,
Novosibirsk
俄罗斯联邦A. Aktanova
Novosibirsk State Medical University
Email: fake@neicon.ru
six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,
Novosibirsk
俄罗斯联邦A. Ermakov
Novosibirsk State Medical University
Email: fake@neicon.ru
six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,
Novosibirsk
俄罗斯联邦N. Knauer
FSBSI “Research Institute of Fundamental and Clinical Immunology”
Email: fake@neicon.ru
PhD student, Clinical Immunopathology Laboratory,
Novosibirsk
俄罗斯联邦I. Mirzaeva
Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD, Researcher, Laboratory of Condensed Matter Physical Chemistry,
Novosibirsk
俄罗斯联邦E. Kovalenko
Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD, Researcher, Laboratory of cluster and supramolecular chemistry,
Novosibirsk
俄罗斯联邦参考
- Wheate N. J. Improving platinum (II)-based anticancer drug delivery using cucurbit [n] urils. Journal of inorganicbiochemistry. 2008, 102, 2060–2066.
- Mirzaeva I. V., Moroz N. K., Andrienko I. V., Kovalenko E. A. Interaction between carboplatin and cucurbit[7]uril studied by means of multinuclear NMR spectroscopy and DFT calculations J. Mol. Struct. 2018, 1163, 68–76.
- Актанова А. А., Ермаков А. А., Пашкина Е. А. Сравнительный анализ противоопухолевого и иммунотоксического действия комплекса кукурбит[7] урила с карбоплатином. Российский иммунологический журнал. 2018, 12(21), 595–597.
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